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Query: NC_004741:2593012:2610423 Shigella flexneri 2a str. 2457T, complete genome

Start: 2610423, End: 2611304, Length: 882

Host Lineage: Shigella flexneri; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This is a highly virulent strain that has been widely used for genetic and clinical research. Causes enteric disease. This genus is named for the Japanese scientist (Shiga) who discovered them in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, and over 1 million deaths worldwide are attributed to them. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. are extremely virulent organisms that require very few cells in order to cause disease. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This organism, along with Shigella sonnei, is the major cause of shigellosis in industrialized countries and is responsible for endemic infections.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_008344:2374761:238049123804912381372882Nitrosomonas eutropha C91, complete genomereplication C family protein2e-171601
NC_008344:669498:683888683888684769882Nitrosomonas eutropha C91, complete genomereplication C family protein2e-171601
NC_008463:1293079:130490213049021305789888Pseudomonas aeruginosa UCBPP-PA14, complete genomeputative replication protein, RepC4e-130464
NC_013365:92973:110691110691111542852Escherichia coli O111:H- str. 11128 plasmid pO111_1, completereplication protein C1e-92340
NC_003384:157158:164829164829165680852Salmonella enterica subsp. enterica serovar Typhi str. CT18 plasmidputative replication protein1e-92340
NC_015186:1126830:114006011400601140914855Acidiphilium multivorum AIU301, complete genomeputative replication protein2e-87322
NC_013722:1816561:186191118619111862543633Xanthomonas albilineans, complete genomeputative replication protein c3e-87321
NC_016745:2028424:204055220405522041454903Oceanimonas sp. GK1 chromosome, complete genomereplication C family protein2e-82305
NC_007508:2783443:279941627994162799865450Xanthomonas campestris pv. vesicatoria str. 85-10, complete genomeputative replication protein C (fragment)3e-49195
NC_006350:1084930:111088011108801111743864Burkholderia pseudomallei K96243 chromosome 1, complete sequenceputative replication protein2e-42172
NC_007508:2783443:279916227991622799371210Xanthomonas campestris pv. vesicatoria str. 85-10, complete genomeputative replication protein C (fragment)6e-24111
NC_012796:1600600:162412916241291625013885Desulfovibrio magneticus RS-1, complete genomereplication protein C family protein2e-23109