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Query: NC_004741:2593012:2596873 Shigella flexneri 2a str. 2457T, complete genome

Start: 2596873, End: 2597064, Length: 192

Host Lineage: Shigella flexneri; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This is a highly virulent strain that has been widely used for genetic and clinical research. Causes enteric disease. This genus is named for the Japanese scientist (Shiga) who discovered them in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, and over 1 million deaths worldwide are attributed to them. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. are extremely virulent organisms that require very few cells in order to cause disease. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This organism, along with Shigella sonnei, is the major cause of shigellosis in industrialized countries and is responsible for endemic infections.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_011601:2806392:281056728105672810758192Escherichia coli O127:H6 str. E2348/69 chromosome, complete genomehypothetical protein2e-29127
NC_006905:2630000:263850626385062638697192Salmonella enterica subsp. enterica serovar Choleraesuis strputative inner membrane protein1e-24112
NC_011283:1307173:132399913239991324190192Klebsiella pneumoniae 342 chromosome, complete genomehypothetical protein2e-21100
NC_020181:5384015:540140954014095401600192Enterobacter aerogenes EA1509E, complete genomePutative inner membrane protein2e-2097.8
NC_020063:1194000:120715312071531207326174Enterobacteriaceae bacterium strain FGI 57, complete genomeProtein of unknown function (DUF2633)1e-1891.7