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Query: NC_004671:1:9960 Enterococcus faecalis V583 plasmid pTEF2, complete sequence

Start: 9960, End: 13877, Length: 3918

Host Lineage: Enterococcus faecalis; Enterococcus; Enterococcaceae; Lactobacillales; Firmicutes; Bacteria

General Information: This strain is one of the first vancomycin-resistant strains isolated. This isolate came from a blood culture derived from a chronically-infected patient in 1987 from Barnes Hospital in St. Louis, Missouri, USA. This strain was found to lack the cytolysin gene and a surface adhesin, Esp, that contributes to urinary tract infections. Mobile genetic elements make up one quarter of the genome. This genera consists of organisms typically found in the intestines of mammals, although through fecal contamination they can appear in sewage, soil, and water. They cause a number of infections that are becoming increasingly a problem due to the number of antibiotic resistance mechanisms these organisms have picked up. Both Enterococcus faecalis and Enterococcus faecium cause similar diseases in humans, and are mainly distinguished by their metabolic capabilities. This opportunistic pathogen can cause urinary tract infections, bacteremia (bacteria in the blood), and infective endocarditis (inflammation of the membrane surrounding the heart), similar to infections caused by Enterococcus faecium. Hospital-acquired infections from this organism are on the rise due to the emergence of antiobiotic resistance strains. Enterococcus faecalis produces a cytolysin toxin that is encoded on various mobile genetic elements, pathogenicity islands, and conjugative plasmids. The cytolysin aids in pathogenesis, possibly by causing destruction of cells such as erythrocytes, which allows access to new nutrients for the organism.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_004669:24672:3511735117390073891Enterococcus faecalis V583 plasmid pTEF1, complete sequenceaggregation substance Asa101890
NC_021175:789958:8012248012248049073684Streptococcus oligofermentans AS 1.3089, complete genomeagglutinin receptor1e-33146
NC_014644:1:1146411464148653402Gardnerella vaginalis ATCC 14019 chromosome, complete genomehypothetical protein4e-31137
NC_009785:213339:2197882197882245154728Streptococcus gordonii str. Challis substr. CH1, complete genomestreptococcal surface protein A7e-29130
NC_009785:213339:2249342249342294334500Streptococcus gordonii str. Challis substr. CH1, complete genomestreptococcal surface protein B8e-29130
NC_004116:1276791:1291338129133812962334896Streptococcus agalactiae 2603V/R, complete genomeagglutinin receptor8e-29130
NC_015600:1161640:1175975117597511808704896Streptococcus pasteurianus ATCC 43144, complete genomeglucan-binding protein C family protein2e-27125
NC_016749:1371997:1383177138317713880814905Streptococcus macedonicus ACA-DC 198, complete genomeAgglutinin receptor4e-27124
NC_011593:580318:5917725917725962144443Bifidobacterium longum subsp. infantis ATCC 15697 chromosome,LPXTG-motif cell wall anchor domain-containing protein5e-26120
NC_017219:580093:5915655915655958604296Bifidobacterium longum subsp. infantis ATCC 15697, complete genomeputative cell surface protein9e-26120
NC_018720:1878201:1897634189763419015393906Bifidobacterium asteroides PRL2011 chromosome, complete genomehypothetical protein2e-1895.9
NC_013203:472679:4767744767744787411968Atopobium parvulum DSM 20469, complete genomeGlucan-binding protein C4e-1275.1
NC_021175:751616:7602377602377650604824Streptococcus oligofermentans AS 1.3089, complete genomecollagen-like surface-anchored protein4e-0861.6
NC_013798:1744118:1759598175959817618922295Streptococcus gallolyticus UCN34, complete genomePutative peptidoglycan linked protein (LPXTG motif)2e-0656.2