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Query: NC_004671:1:1280 Enterococcus faecalis V583 plasmid pTEF2, complete sequence

Start: 1280, End: 2437, Length: 1158

Host Lineage: Enterococcus faecalis; Enterococcus; Enterococcaceae; Lactobacillales; Firmicutes; Bacteria

General Information: This strain is one of the first vancomycin-resistant strains isolated. This isolate came from a blood culture derived from a chronically-infected patient in 1987 from Barnes Hospital in St. Louis, Missouri, USA. This strain was found to lack the cytolysin gene and a surface adhesin, Esp, that contributes to urinary tract infections. Mobile genetic elements make up one quarter of the genome. This genera consists of organisms typically found in the intestines of mammals, although through fecal contamination they can appear in sewage, soil, and water. They cause a number of infections that are becoming increasingly a problem due to the number of antibiotic resistance mechanisms these organisms have picked up. Both Enterococcus faecalis and Enterococcus faecium cause similar diseases in humans, and are mainly distinguished by their metabolic capabilities. This opportunistic pathogen can cause urinary tract infections, bacteremia (bacteria in the blood), and infective endocarditis (inflammation of the membrane surrounding the heart), similar to infections caused by Enterococcus faecium. Hospital-acquired infections from this organism are on the rise due to the emergence of antiobiotic resistance strains. Enterococcus faecalis produces a cytolysin toxin that is encoded on various mobile genetic elements, pathogenicity islands, and conjugative plasmids. The cytolysin aids in pathogenesis, possibly by causing destruction of cells such as erythrocytes, which allows access to new nutrients for the organism.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_015921:425225:4252254252254264391215Borrelia bissettii DN127 chromosome, complete genometraB family protein1e-36154
NC_013440:625867:6342406342406354151176Haliangium ochraceum DSM 14365, complete genomeTraB family protein6e-36151
NC_006156:427358:4273584273584285721215Borrelia garinii PBi chromosome linear, complete sequencepheromone shutdown protein1e-35150
NC_013741:302415:3178713178713190101140Archaeoglobus profundus DSM 5631, complete genomeTraB family protein2e-35150
NC_017238:427482:4274824274824286961215Borrelia afzelii PKo chromosome, complete genometraB family protein3e-35149
NC_008277:428926:4289264289264301401215Borrelia afzelii PKo, complete genomepheromone shutdown protein3e-35149
NC_003901:1568000:1572566157256615740711506Methanosarcina mazei Go1, complete genomepheromone shutdown protein5e-33142
NC_020389:1346358:1348008134800813495461539Methanosarcina mazei Tuc01, complete genomePheromone shutdown protein7e-33141
NC_015574:2145000:2168677216867721698371161Methanobacterium sp. SWAN-1 chromosome, complete genomeTraB family protein2e-32140
NC_008789:7347:1422514225154241200Halorhodospira halophila SL1, complete genomeTraB family protein1e-31137
NC_014253:1818000:1837210183721018385981389Methanohalobium evestigatum Z-7303 chromosome, complete genomeTraB family protein3e-31136
NC_009515:967600:9864779864779876551179Methanobrevibacter smithii ATCC 35061, complete genomepheromone shutdown protein TraB9e-30131
NC_015562:1460124:1481912148191214830781167Methanotorris igneus Kol 5 chromosome, complete genomeTraB family protein4e-29129
NC_015216:328598:3291733291733303271155Methanobacterium sp. AL-21 chromosome, complete genomeTraB family protein6e-29128
NC_013665:2495234:2513168251316825144151248Methanocella paludicola SANAE, complete genomeTraB family protein3e-25116
NC_015948:1131628:1131628113162811331601533Haloarcula hispanica ATCC 33960 chromosome chromosome I, completeputative plasmid transfer protein2e-1170.5