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Query: NC_004557:32094:38332 Clostridium tetani E88, complete genome

Start: 38332, End: 38408, Length: 77

Host Lineage: Clostridium tetani; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain is a virulent nonsporulating variant of strain Massachusetts used in vaccine production. Causes tetanus. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Known opportunistic toxin-producing pathogens in animals and humans. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This organism causes tetanus (lockjaw) in humans. At the tissue level, the bacterium then releases an exotoxin called tetanospasmin that causes certain nervous system irregularities by means of retrograde tramsmission through neurons to the brain. If nervous impulses cannot be checked by normal inhibitory mechanisms, it produces the generalized muscular spasms characteristic of tetanus.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_004557:2777291:27937482793748279382477Clostridium tetani E88, complete genometRNA-Met4e-0650.1
NC_014328:4471995:44811574481157448123377Clostridium ljungdahlii ATCC 49587 chromosome, complete genometRNA-Met4e-0650.1
NC_008593:2527064:25333832533383253345977Clostridium novyi NT, complete genometRNA-Met4e-0650.1
NC_008262:67711:90676906769075277Clostridium perfringens SM101, complete genometRNA-Met4e-0650.1
NC_014328:1:14430144301450677Clostridium ljungdahlii ATCC 49587 chromosome, complete genometRNA-Met4e-0650.1
NC_010674:3581044:35886293588629358870577Clostridium botulinum B str. Eklund 17B, complete genometRNA-Met4e-0650.1
NC_010723:1:14393143931446977Clostridium botulinum E3 str. Alaska E43, complete genometRNA-Met4e-0650.1
NC_008261:1:14992149921506877Clostridium perfringens ATCC 13124, complete genometRNA-Met4e-0650.1
NC_010723:3395187:34029943402994340307077Clostridium botulinum E3 str. Alaska E43, complete genometRNA-Met4e-0650.1
NC_010674:1:14441144411451777Clostridium botulinum B str. Eklund 17B, complete genometRNA-Met4e-0650.1