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Query: NC_004557:2607073:2619395 Clostridium tetani E88, complete genome

Start: 2619395, End: 2620948, Length: 1554

Host Lineage: Clostridium tetani; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain is a virulent nonsporulating variant of strain Massachusetts used in vaccine production. Causes tetanus. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Known opportunistic toxin-producing pathogens in animals and humans. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This organism causes tetanus (lockjaw) in humans. At the tissue level, the bacterium then releases an exotoxin called tetanospasmin that causes certain nervous system irregularities by means of retrograde tramsmission through neurons to the brain. If nervous impulses cannot be checked by normal inhibitory mechanisms, it produces the generalized muscular spasms characteristic of tetanus.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_020291:4033000:4044779404477940463441566Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genomecitrate lyase alpha chain2e-154546
NC_017316:2710021:2727246272724627287781533Enterococcus faecalis OG1RF chromosome, complete genomecitrate (pro-3S)-lyase9e-151533
NC_004668:3184319:3205884320588432072961413Enterococcus faecalis V583, complete genomecitrate lyase, alpha subunit1e-149530
NC_014364:2322269:2362003236200323635591557Spirochaeta smaragdinae DSM 11293 chromosome, complete genomecitrate lyase, alpha subunit1e-147523
NC_015224:1914833:1914833191483319163501518Yersinia enterocolitica subsp. palearctica 105.5R(r) chromosome,citrate lyase alpha chain4e-141501
NC_015663:1:2549254940661518Enterobacter aerogenes KCTC 2190 chromosome, complete genomecitrate lyase subunit alpha4e-137488
NC_014632:336000:3443183443183458771560Ilyobacter polytropus DSM 2926 chromosome, complete genomecitrate lyase subunit alpha5e-135481
NC_004557:2711702:2717037271703727185781542Clostridium tetani E88, complete genomecitrate lyase alpha chain9e-134477
NC_015389:616430:6775696775696791071539Coriobacterium glomerans PW2 chromosome, complete genomecitrate lyase, alpha subunit1e-133476
NC_014328:4387303:4410728441072844122691542Clostridium ljungdahlii ATCC 49587 chromosome, complete genomecitrate lyase subunit alpha3e-130465
NC_009633:3457185:3477227347722734787681542Alkaliphilus metalliredigens QYMF chromosome, complete genomecitrate lyase subunit alpha2e-122439
NC_015578:3011133:3025967302596730273761410Treponema primitia ZAS-2 chromosome, complete genomecitrate lyase subunit alpha8e-120431
NC_013926:920279:9318039318039333381536Aciduliprofundum boonei T469 chromosome, complete genomecitrate lyase, alpha subunit4e-112405
NC_014011:472650:4758124758124773771566Aminobacterium colombiense DSM 12261 chromosome, complete genomecitrate lyase, alpha subunit2e-104380