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Query: NC_004557:2552418:2554683 Clostridium tetani E88, complete genome

Start: 2554683, End: 2555321, Length: 639

Host Lineage: Clostridium tetani; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain is a virulent nonsporulating variant of strain Massachusetts used in vaccine production. Causes tetanus. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Known opportunistic toxin-producing pathogens in animals and humans. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This organism causes tetanus (lockjaw) in humans. At the tissue level, the bacterium then releases an exotoxin called tetanospasmin that causes certain nervous system irregularities by means of retrograde tramsmission through neurons to the brain. If nervous impulses cannot be checked by normal inhibitory mechanisms, it produces the generalized muscular spasms characteristic of tetanus.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_012563:3729817:375238137523813753025645Clostridium botulinum A2 str. Kyoto, complete genomeintegral membrane protein TIGR019065e-1787.8
NC_009697:3463736:348629534862953486939645Clostridium botulinum A str. ATCC 19397 chromosome, completehypothetical protein5e-1787.8
NC_009495:3502000:351030735103073510951645Clostridium botulinum A str. ATCC 3502 chromosome, complete genomehypothetical protein5e-1787.8
NC_017297:3594000:360255736025573603201645Clostridium botulinum F str. 230613 chromosome, complete genomeintegral membrane protein6e-1787.4
NC_009699:3581376:360394136039413604585645Clostridium botulinum F str. Langeland chromosome, complete genomehypothetical protein6e-1787.4
NC_010520:3580000:358817935881793588823645Clostridium botulinum A3 str. Loch Maree, complete genomeintegral membrane protein TIGR019062e-1685.5
NC_007530:1459412:146091814609181461604687Bacillus anthracis str. 'Ames Ancestor', complete genomehypothetical protein1e-1480.1
NC_005945:1459357:146087214608721461558687Bacillus anthracis str. Sterne, complete genomehypothetical protein1e-1480.1
NC_014393:3650957:365335536533553653984630Clostridium cellulovorans 743B chromosome, complete genomeintegral membrane protein TIGR019062e-1375.9
NC_021182:1473535:148854114885411489209669Clostridium pasteurianum BC1, complete genomeintegral membrane protein TIGR019066e-1374.3