Pre_GI: BLASTP Hits

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Query: NC_004557:2475030:2475030 Clostridium tetani E88, complete genome

Start: 2475030, End: 2476205, Length: 1176

Host Lineage: Clostridium tetani; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain is a virulent nonsporulating variant of strain Massachusetts used in vaccine production. Causes tetanus. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Known opportunistic toxin-producing pathogens in animals and humans. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This organism causes tetanus (lockjaw) in humans. At the tissue level, the bacterium then releases an exotoxin called tetanospasmin that causes certain nervous system irregularities by means of retrograde tramsmission through neurons to the brain. If nervous impulses cannot be checked by normal inhibitory mechanisms, it produces the generalized muscular spasms characteristic of tetanus.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_010718:2513917:2528725252872525326423918Natranaerobius thermophilus JW/NM-WN-LF, complete genomecopper amine oxidase domain protein3e-0860.1
NC_003228:3212500:3218989321898932203231335Bacteroides fragilis NCTC 9343, complete genomeputative lipoprotein8e-0755.1
NC_010379:110760:1107601107601141823423Clostridium botulinum B1 str. Okra plasmid pCLD, complete sequenceputative viral A-type inclusion protein1e-0861.6
NC_012673:1046016:105143910514391052206768Exiguobacterium sp. AT1b, complete genometransglutaminase domain protein8e-0755.1
NC_011898:649000:6490406490406502361197Clostridium cellulolyticum H10, complete genometransglutaminase domain protein5e-61235
NC_007503:2243902:224936922493692250001633Carboxydothermus hydrogenoformans Z-2901, complete genometransglutaminase family protein7e-1065.5
NC_016012:1010405:1034728103472810358581131Candidatus Arthromitus sp. SFB-rat-Yit, complete genometransglutaminase-like enzyme cysteine protease4e-44179
NC_008593:1859861:187071518707151871470756Clostridium novyi NT, complete genometransglutaminase-like enzyme, putative cysteine protease2e-1584