Pre_GI: BLASTP Hits

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Query: NC_004557:2037500:2052894 Clostridium tetani E88, complete genome

Start: 2052894, End: 2053541, Length: 648

Host Lineage: Clostridium tetani; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain is a virulent nonsporulating variant of strain Massachusetts used in vaccine production. Causes tetanus. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Known opportunistic toxin-producing pathogens in animals and humans. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This organism causes tetanus (lockjaw) in humans. At the tissue level, the bacterium then releases an exotoxin called tetanospasmin that causes certain nervous system irregularities by means of retrograde tramsmission through neurons to the brain. If nervous impulses cannot be checked by normal inhibitory mechanisms, it produces the generalized muscular spasms characteristic of tetanus.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_006510:2910000:291133429113342912236903Geobacillus kaustophilus HTA426, complete genomehypothetical protein1e-31136
NC_009328:2905000:290756129075612908463903Geobacillus thermodenitrificans NG80-2 chromosome, complete genomehypothetical protein1e-29129
NC_018681:2985078:298899629889962989841846Nocardia brasiliensis ATCC 700358 chromosome, complete genomemethyltransferase2e-1582
NC_011832:1122268:114197111419711142858888Candidatus Methanosphaerula palustris E1-9c, complete genomemethyltransferase6e-1477.4
NC_020126:6344827:636177663617766362663888Myxococcus stipitatus DSM 14675, complete genomehypothetical protein6e-1374.3
NC_007005:5127414:513221451322145133149936Pseudomonas syringae pv. syringae B728a, complete genomeProtein of unknown function DUF1426e-1374.3
NC_003552:3058523:3062537306253730635891053Methanosarcina acetivorans C2A, complete genomehypothetical protein3e-1271.6
NC_016948:678939:714012714012714908897Mycobacterium intracellulare MOTT-64 chromosome, complete genomehypothetical protein4e-1065.1
NC_009074:1470689:1494182149418214959961815Burkholderia pseudomallei 668 chromosome I, complete sequencetranscriptional regulator, MerR family/putative methyltransferase7e-1063.9
NC_018681:3541484:354181335418133542697885Nocardia brasiliensis ATCC 700358 chromosome, complete genomemethyltransferase2e-0858.9
NC_007434:1809946:1859420185942018613991980Burkholderia pseudomallei 1710b chromosome I, complete sequencetranscriptional regulator, MerR family2e-0755.8
NC_008942:1706191:172993517299351730831897Methanocorpusculum labreanum Z, complete genomehypothetical protein3e-0755.1