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Query: NC_004557:1553000:1560754 Clostridium tetani E88, complete genome

Start: 1560754, End: 1561422, Length: 669

Host Lineage: Clostridium tetani; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain is a virulent nonsporulating variant of strain Massachusetts used in vaccine production. Causes tetanus. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Known opportunistic toxin-producing pathogens in animals and humans. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This organism causes tetanus (lockjaw) in humans. At the tissue level, the bacterium then releases an exotoxin called tetanospasmin that causes certain nervous system irregularities by means of retrograde tramsmission through neurons to the brain. If nervous impulses cannot be checked by normal inhibitory mechanisms, it produces the generalized muscular spasms characteristic of tetanus.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_009698:2171151:218164721816472182375729Clostridium botulinum A str. Hall chromosome, complete genomehypothetical protein1e-78292
NC_009697:2173000:218142821814282182156729Clostridium botulinum A str. ATCC 19397 chromosome, completehypothetical protein1e-78292
NC_009495:2244774:225278622527862253514729Clostridium botulinum A str. ATCC 3502 chromosome, complete genomehypothetical protein1e-78292
NC_012563:2384500:239619023961902396918729Clostridium botulinum A2 str. Kyoto, complete genomehypothetical protein2e-78291
NC_009699:2287893:230199923019992302715717Clostridium botulinum F str. Langeland chromosome, complete genomehypothetical protein3e-78291
NC_012658:2295536:231015623101562310884729Clostridium botulinum Ba4 str. 657 chromosome, complete genomehypothetical protein2e-77288
NC_017297:2288000:230222423022242302829606Clostridium botulinum F str. 230613 chromosome, complete genomehypothetical protein1e-58226
NC_010723:1465097:147799714779971478665669Clostridium botulinum E3 str. Alaska E43, complete genomehypothetical protein1e-56219
NC_010674:1496500:150778415077841508452669Clostridium botulinum B str. Eklund 17B, complete genomehypothetical protein3e-55214
NC_009922:2556033:257057325705732571262690Alkaliphilus oremlandii OhILAs, complete genomeconserved hypothetical protein1e-45182
NC_014328:4316008:432896843289684329738771Clostridium ljungdahlii ATCC 49587 chromosome, complete genomeputative ethanolamine utilization cobalamin adenosyltransferase2e-45182
NC_014328:1286407:129198012919801292753774Clostridium ljungdahlii ATCC 49587 chromosome, complete genomeputative ethanolamine utilization cobalamin adenosyltransferase1e-44179
NC_010001:1745089:176098117609811761616636Clostridium phytofermentans ISDg, complete genomehypothetical protein2e-30132
NC_016584:5625975:563775656377565638424669Desulfosporosinus orientis DSM 765 chromosome, complete genomeethanolamine utilization cobalamin adenosyltransferase3e-24112
NC_009633:3933941:394725939472593947897639Alkaliphilus metalliredigens QYMF chromosome, complete genomehypothetical protein2e-21102