Pre_GI: BLASTP Hits

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Query: NC_004557:1141558:1157959 Clostridium tetani E88, complete genome

Start: 1157959, End: 1159659, Length: 1701

Host Lineage: Clostridium tetani; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain is a virulent nonsporulating variant of strain Massachusetts used in vaccine production. Causes tetanus. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Known opportunistic toxin-producing pathogens in animals and humans. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This organism causes tetanus (lockjaw) in humans. At the tissue level, the bacterium then releases an exotoxin called tetanospasmin that causes certain nervous system irregularities by means of retrograde tramsmission through neurons to the brain. If nervous impulses cannot be checked by normal inhibitory mechanisms, it produces the generalized muscular spasms characteristic of tetanus.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_014328:3434478:3451376345137634527341359Clostridium ljungdahlii ATCC 49587 chromosome, complete genomehypothetical protein6e-86318
NC_009495:2479465:2496915249691524988761962Clostridium botulinum A str. ATCC 3502 chromosome, complete genomehypothetical protein7e-34145
NC_014652:801653:8119228119228136131692Caldicellulosiruptor hydrothermalis 108 chromosome, completehypothetical protein2e-23111
NC_009633:2592000:2610639261063926116551017Alkaliphilus metalliredigens QYMF chromosome, complete genomehypothetical protein4e-1273.6
NC_009617:1897887:1919633191963319206431011Clostridium beijerinckii NCIMB 8052 chromosome, complete genomehypothetical protein4e-1273.6
NC_009706:2023912:2032684203268420340151332Clostridium kluyveri DSM 555 chromosome, complete genomehypothetical protein3e-0757.4
NC_015520:595532:6048356048356065141680Mahella australiensis 50-1 BON chromosome, complete genomehypothetical protein3e-0757