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Query: NC_004557:1141558:1157449 Clostridium tetani E88, complete genome

Start: 1157449, End: 1157922, Length: 474

Host Lineage: Clostridium tetani; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain is a virulent nonsporulating variant of strain Massachusetts used in vaccine production. Causes tetanus. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Known opportunistic toxin-producing pathogens in animals and humans. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This organism causes tetanus (lockjaw) in humans. At the tissue level, the bacterium then releases an exotoxin called tetanospasmin that causes certain nervous system irregularities by means of retrograde tramsmission through neurons to the brain. If nervous impulses cannot be checked by normal inhibitory mechanisms, it produces the generalized muscular spasms characteristic of tetanus.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_015675:6651899:666173466617346662183450Mesorhizobium opportunistum WSM2075 chromosome, complete genome3e-0857.4
NC_014923:5721686:573385457338545734204351Mesorhizobium ciceri biovar biserrulae WSM1271 chromosome, completehypothetical protein4e-0857
NC_015675:6276357:628852562885256288875351Mesorhizobium opportunistum WSM2075 chromosome, complete genomehypothetical protein4e-0857
NC_019973:5650646:566281456628145663164351Mesorhizobium australicum WSM2073, complete genomehypothetical protein4e-0857
NC_008593:2020473:2040892204089220422081317Clostridium novyi NT, complete genomeMetallo-beta-lactamase superfamily protein7e-0856.2
NC_002678:6608697:662161366216136622017405Mesorhizobium loti MAFF303099, complete genomehypothetical protein7e-0856.2
NC_002678:341996:350305350305351066762Mesorhizobium loti MAFF303099, complete genomesuccinoglycan biosynthesis protein exoI1e-0755.8
NC_017322:1260526:126227212622721262583312Sinorhizobium meliloti BL225C chromosome, complete genomesuccinoglycan biosynthesis protein ExoI2e-0754.7
NC_021182:554000:554135554135554281147Clostridium pasteurianum BC1, complete genome3e-0754.3
NC_012988:4262631:426263142626314263314684Methylobacterium extorquens DM4, complete genomenuclease6e-0753.1
NC_015425:2277570:2294149229414922953271179Clostridium botulinum BKT015925 chromosome, complete genomemetallo-beta-lactamase superfamily protein4e-0650.8
NC_014328:3434478:344471034447103445321612Clostridium ljungdahlii ATCC 49587 chromosome, complete genomehypothetical protein5e-0650.1