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Query: NC_004557:1141558:1150593 Clostridium tetani E88, complete genome

Start: 1150593, End: 1151060, Length: 468

Host Lineage: Clostridium tetani; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain is a virulent nonsporulating variant of strain Massachusetts used in vaccine production. Causes tetanus. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Known opportunistic toxin-producing pathogens in animals and humans. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This organism causes tetanus (lockjaw) in humans. At the tissue level, the bacterium then releases an exotoxin called tetanospasmin that causes certain nervous system irregularities by means of retrograde tramsmission through neurons to the brain. If nervous impulses cannot be checked by normal inhibitory mechanisms, it produces the generalized muscular spasms characteristic of tetanus.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_021182:3347076:336750933675093367952444Clostridium pasteurianum BC1, complete genomehypothetical protein4e-1580.1
NC_009089:1093832:110961811096181110106489Clostridium difficile 630, complete genomehypothetical protein7e-1269.7
NC_021182:4367736:437385243738524374295444Clostridium pasteurianum BC1, complete genomeDNA-directed RNA polymerase specialized sigma subunit2e-0961.6
NC_010516:2328288:233173123317312332210480Clostridium botulinum B1 str. Okra, complete genomepossible sigma factor6e-0856.6
NC_014393:4323368:432463643246364325088453Clostridium cellulovorans 743B chromosome, complete genomehypothetical protein2e-0755.1
NC_015425:1295261:130716513071651307593429Clostridium botulinum BKT015925 chromosome, complete genomeputative sigma factor6e-0753.1
NC_008261:1787345:180992018099201810381462Clostridium perfringens ATCC 13124, complete genomeputative DNA-binding protein3e-0650.8