Pre_GI: BLASTP Hits

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Query: NC_004432:32500:48615 Mycoplasma penetrans HF-2, complete genome

Start: 48615, End: 49175, Length: 561

Host Lineage: Mycoplasma penetrans; Mycoplasma; Mycoplasmataceae; Mycoplasmatales; Tenericutes; Bacteria

General Information: This strain has been isolated from the tracheal aspirate of a previously healthy HIV-negative patient with severe respiratory symptoms caused by this infection. Causes urogenital and respiratory disease. This genus currently comprises more than 120 obligate parasitic species found in a wide spectrum of hosts, including humans, animals, insects and plants. The primary habitats of human and animal mycoplasmas are mucous membranes of the respiratory and urogenital tracts, eyes, mammary glands and the joints. Infection that proceeds through attachment of the bacteria to the host cell via specialized surface proteins, adhesins, and subsequent invasion, results in prolonged intracellular persistence that may cause lethality. Once detected in association with their eukaryotic host tissue, most mycoplasmas can be cultivated in the absence of a host if their extremely fastidious growth requirements are met. The latter is one of the major traits that puts them in the separate taxonomic group of microorganisms, class Mollicutes. The cell membrane is rich in protein components (up to two thirds of the membrane mass) that largely consists of highly structurally adaptive lipoproteins employed in invading the host immune system, attachment to the host cells, and pathogenic invasion. Cell division proceeds via normal binary fission or via elongation of a parental cell to form multinucleated filaments and the subsequent breakup to form coccoid bodies.Mycoplasmas carry the smallest genomes of self-replicating cells (less than 500 recognizable coding regions), which is one of the reasons they were among the first microorganisms selected for the genome-sequencing projects. During their evolution, mycoplasmas appear to have lost all of the genes involved in amino acid and cofactor biosynthesis, synthesis of the cell wall and lipid metabolism, resulting in a requirement for the full spectrum of substrates and cofactors taken up from the host or from the complex artificial culture medium. They have lost a number of genes involved in cellular processes, such as cell division, heat shock response, regulatory genes, the two-component signal transduction systems, histidine protein kinases or their target response regulators, and most transcription factors. The majority of mycoplasmas are deficient in genes coding for components of intermediary and energy metabolism and thus are dependent mostly on glycolysis as an ATP-generating pathway. This organism infects humans in the urogenital and respiratory tracts though invasion of tissues. The disease is mainly associated with HIV-1 infection, particularly in the homosexual population, and is very persistent and believed to contribute to the deterioration of the immune system during HIV. Mycoplasma penetrans infection has also been suggested to be a primary cause of some forms of human urethritis and respiratory disease in non-HIV individuals.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_013171:416279:427361427361427948588Anaerococcus prevotii DSM 20548, complete genomeGTP-binding protein HSR1-related2e-27122
NC_008260:2992813:299758029975802998206627Alcanivorax borkumensis SK2, complete genomeGTP-binding protein3e-25114
NC_007484:580106:596787596787597389603Nitrosococcus oceani ATCC 19707, complete genomeGTP-binding protein7e-24110
NC_016584:5420823:543359254335925434191600Desulfosporosinus orientis DSM 765 chromosome, complete genomeribosome biogenesis GTP-binding protein YsxC/EngB8e-24109
NC_012440:1215838:124641312464131247024612Persephonella marina EX-H1, complete genomeribosome biogenesis GTP-binding protein YsxC2e-23108
NC_016148:1105669:112376511237651124397633Thermovirga lienii DSM 17291 chromosome, complete genomeribosome biogenesis GTP-binding protein YsxC4e-23107
NC_013132:8871718:887224788722478872855609Chitinophaga pinensis DSM 2588, complete genomesmall GTP-binding protein1e-22105
NC_012796:2683711:268807826880782688704627Desulfovibrio magneticus RS-1, complete genomeprobable GTP-binding protein EngB6e-22103
NC_013642:1317114:134620913462091346796588Thermotoga naphthophila RKU-10, complete genomeribosome biogenesis GTP-binding protein YsxC6e-22103
NC_013315:3689422:369271436927143693298585Clostridium difficile CD196 chromosome, complete genomeribosome biogenesis GTP-binding protein YsxC2e-21102
NC_015424:4251369:427380142738014274418618Aeromonas veronii B565 chromosome, complete genomeGTPase EngB2e-21102
NC_016001:2980245:299589329958932996507615Flavobacterium branchiophilum, complete genomeputative GTP-binding protein EngB2e-21101
NC_009486:1293510:132258413225841323171588Thermotoga petrophila RKU-1 chromosome, complete genomeribosome biogenesis GTP-binding protein YsxC3e-21101
NC_010483:1385000:138501513850151385602588Thermotoga sp. RQ2, complete genomesmall GTP-binding protein5e-21100
NC_014934:2519999:251999925199992520625627Cellulophaga algicola DSM 14237 chromosome, complete genomegtp-binding protein engb6e-21100
NC_014008:354292:357022357022357672651Coraliomargarita akajimensis DSM 45221 chromosome, complete genomeribosome biogenesis GTP-binding protein YsxC1e-2099.4
NC_017501:1863417:188626818862681886897630Neisseria meningitidis 8013, complete genomeGTP-binding protein EngB2e-2098.6
NC_015391:1323171:132470113247011325288588Carnobacterium sp. 17-4 chromosome, complete genomeribosome biogenesis GTP-binding protein YsxC3e-2098.2
NC_009614:3748950:376615737661573766759603Bacteroides vulgatus ATCC 8482 chromosome, complete genomeribosome biogenesis GTP-binding protein YsxC3e-2098.2
NC_014622:4361553:438081943808194381430612Paenibacillus polymyxa SC2 chromosome, complete genomeGTPase engb3e-2098.2
NC_019814:125611:129555129555130223669Candidatus Kinetoplastibacterium blastocrithidii (ex StrigomonasGTP-binding protein4e-1994.4
NC_016745:546249:561728561728562363636Oceanimonas sp. GK1 chromosome, complete genomeGTP-binding protein YsxC4e-1994.4
NC_013939:1841890:185835418583541858929576Deferribacter desulfuricans SSM1, complete genomeGTP-binding protein6e-1993.6
NC_015731:2950874:295961629596162960212597Nitrosomonas sp. Is79A3 chromosome, complete genomeGTP-binding protein engB6e-1993.6
NC_016629:3308329:331919933191993319789591Desulfovibrio africanus str. Walvis Bay chromosome, completeGTP-binding protein engB1e-1893.2
NC_016751:1604048:160946816094681610046579Marinitoga piezophila KA3 chromosome, complete genomeribosome biogenesis GTP-binding protein YsxC/EngB1e-1892.8
NC_019970:813917:820425820425821021597Thermoanaerobacterium thermosaccharolyticum M0795, complete genomeribosome biogenesis GTP-binding protein YsxC/EngB1e-1892.8
NC_009697:3409185:341134334113433411927585Clostridium botulinum A str. ATCC 19397 chromosome, completeribosome biogenesis GTP-binding protein YsxC1e-1892.4
NC_019907:1411124:143568914356891436330642Liberibacter crescens BT-1 chromosome, complete genomeGTP-binding protein EngB2e-1892
NC_016803:465453:481893481893482474582Desulfovibrio desulfuricans ND132 chromosome, complete genomeribosome biogenesis GTP-binding protein YsxC2e-1892
NC_020299:764526:768766768766769371606Candidatus Kinetoplastibacterium oncopeltii TCC290E, completeGTP-binding protein3e-1891.7
NC_000963:110500:112320112320112964645Rickettsia prowazekii str. Madrid E, complete genomeGTP-binding protein2e-1891.7
NC_017048:452000:454389454389455033645Rickettsia prowazekii str. GvV257 chromosome, complete genomeGTP-binding protein YsxC2e-1891.7
NC_017049:109000:110519110519111163645Rickettsia prowazekii str. Chernikova chromosome, complete genomeGTP-binding protein YsxC2e-1891.7
NC_017050:110500:112318112318112962645Rickettsia prowazekii str. Katsinyian chromosome, complete genomeGTP-binding protein YsxC2e-1891.7
NC_017051:109000:110522110522111166645Rickettsia prowazekii str. Dachau chromosome, complete genomeGTP-binding protein YsxC2e-1891.7
NC_017056:110500:112328112328112972645Rickettsia prowazekii str. BuV67-CWPP chromosome, complete genomeGTP-binding protein YsxC2e-1891.7
NC_017057:110000:112445112445113089645Rickettsia prowazekii str. RpGvF24 chromosome, complete genomeGTP-binding protein YsxC2e-1891.7
NC_010336:1670000:167518716751871675780594Francisella philomiragia subsp. philomiragia ATCC 25017, completeATP/GTP-binding protein4e-1891.3
NC_006570:650291:655449655449656042594Francisella tularensis subsp. tularensis Schu 4, complete genomeATP/GTP-binding protein4e-1891.3
NC_008245:650243:655401655401655994594Francisella tularensis subsp. tularensis FSC 198, complete genomeATP/GTP-binding protein4e-1891.3
NC_016933:726197:731355731355731948594Francisella tularensis TIGB03 chromosome, complete genomeGTP-binding protein EngB4e-1891.3
NC_016937:650290:655448655448656041594Francisella tularensis subsp. tularensis TI0902 chromosome,GTP-binding protein EngB4e-1891.3
NC_009850:972692:984257984257984859603Arcobacter butzleri RM4018, complete genomeputative ATP /GTP binding protein3e-1891.3
NC_017187:937649:949213949213949815603Arcobacter butzleri ED-1, complete genomeputative ATP /GTP binding protein3e-1891.3
NC_009663:1237336:125820112582011258842642Sulfurovum sp. NBC37-1, complete genomeGTP-binding protein5e-1890.9
NC_010001:473354:485065485065485670606Clostridium phytofermentans ISDg, complete genomeGTP-binding protein HSR1-related6e-1890.5
NC_014774:293800:318252318252318830579Candidatus Liberibacter solanacearum CLso-ZC1 chromosome, completeGTPase EngB8e-1890.1
NC_012968:325529:325529325529326164636Methylotenera mobilis JLW8, complete genomeGTP-binding protein HSR1-related7e-1890.1
NC_004663:1365429:136933213693321369940609Bacteroides thetaiotaomicron VPI-5482, complete genomeputative GTP-binding protein6e-1890.1
NC_009749:879174:884263884263884829567Francisella tularensis subsp. holarctica FTA, complete genomeATP/GTP-binding protein1e-1789.7
NC_009257:1023696:103410310341031034696594Francisella tularensis subsp. tularensis WY96-3418 chromosome,ribosome biogenesis GTP-binding protein YsxC1e-1789.4
NC_008601:1094041:110446711044671105060594Francisella tularensis subsp. novicida U112, complete genomeATP/GTP-binding protein1e-1789.4
NC_008369:880975:886133886133886726594Francisella tularensis subsp. holarctica OSU18, complete genomeGTPase1e-1789.4
NC_007880:877317:882475882475883068594Francisella tularensis subsp. holarctica, complete genomeATP/GTP-binding protein1e-1789.4
NC_015581:1891409:189699718969971897617621Thioalkalimicrobium cyclicum ALM1 chromosome, complete genomeGTP-binding protein engB2e-1789
NC_017294:327433:339766339766340332567Candidatus Arthromitus sp. SFB-mouse-Yit, complete genomeribosome biogenesis GTP-binding protein YsxC2e-1789
NC_017208:4435573:445171144517114452307597Bacillus thuringiensis serovar chinensis CT-43 chromosome, completeGTPase EngB3e-1788.2
NC_011772:4397599:441444844144484415044597Bacillus cereus G9842, complete genomeGTP-binding protein3e-1788.2
NC_014171:4317520:433704343370434337639597Bacillus thuringiensis BMB171 chromosome, complete genomeGTPase EngB7e-1786.7
NC_011725:4428726:444679944467994447395597Bacillus cereus B4264 chromosome, complete genomeribosome biogenesis GTP-binding protein YsxC7e-1786.7
NC_004722:4405363:442213444221344422730597Bacillus cereus ATCC 14579, complete genomeGTP-binding protein7e-1786.7
NC_017028:180219:198934198934199572639Candidatus Rickettsia amblyommii str. GAT-30V chromosome, completeGTP-binding protein YsxC9e-1786.3
NC_020409:437781:462002462002462583582Desulfovibrio piezophilus str. nov C1TLV30 chromosome, completeputative GTP-binding protein engB2e-1685.5
NC_012472:4255729:428096542809654281561597Bacillus cereus 03BB102, complete genomeGTP-binding protein2e-1685.5
NC_008600:4263505:428256442825644283160597Bacillus thuringiensis str. Al Hakam, complete genomeGTP-binding protein2e-1685.5
NC_003997:4273579:427623342762334276829597Bacillus anthracis str. Ames, complete genomeGTP-binding protein2e-1685.5
NC_014335:4181710:420695042069504207546597Bacillus cereus biovar anthracis str. CI chromosome, completeGTP-binding protein2e-1685.5
NC_003909:4209385:422950242295024230098597Bacillus cereus ATCC 10987, complete genomeGTP-binding protein2e-1685.5
NC_011773:4296082:431393343139334314529597Bacillus cereus AH820 chromosome, complete genomeribosome biogenesis GTP-binding protein YsxC2e-1685.5
NC_011969:4140000:416414541641454164741597Bacillus cereus Q1 chromosome, complete genomeribosome biogenesis GTP-binding protein ysxc2e-1685.5
NC_012659:4273606:427626042762604276856597Bacillus anthracis str. A0248, complete genomeribosome biogenesis GTP-binding protein YsxC2e-1685.5
NC_016779:4217171:423381142338114234407597Bacillus cereus F837/76 chromosome, complete genomeGTP-binding protein EngB like protein2e-1685.5
NC_017044:130000:133495133495134133639Rickettsia parkeri str. Portsmouth chromosome, complete genomeGTP-binding protein YsxC2e-1685.1
NC_009714:265098:268834268834269466633Campylobacter hominis ATCC BAA-381, complete genomeGTP-binding protein2e-1685.1
NC_006142:33268:480984809848742645Rickettsia typhi str. Wilmington, complete genomeGTP-binding protein3e-1684.7
NC_017062:33268:480654806548709645Rickettsia typhi str. B9991CWPP chromosome, complete genomeGTP-binding protein YsxC3e-1684.7
NC_017066:33268:480984809848742645Rickettsia typhi str. TH1527 chromosome, complete genomeGTP-binding protein YsxC3e-1684.7
NC_016929:109500:111144111144111803660Rickettsia canadensis str. CA410 chromosome, complete genomeGTP-binding protein YsxC3e-1684.7
NC_019815:589762:591716591716592345630Candidatus Kinetoplastibacterium crithidii (ex Angomonas deaneiGTP-binding protein3e-1684.3
NC_009879:107890:110321110321110980660Rickettsia canadensis str. McKiel, complete genomeGTP-binding protein6e-1683.6
NC_013522:991649:994349994349994954606Thermanaerovibrio acidaminovorans DSM 6589, complete genomesmall GTP-binding protein3e-1581.3
NC_015563:1129469:115511711551171155869753Delftia sp. Cs1-4 chromosome, complete genomeGTP-binding protein engB3e-1581.3
NC_009464:1531847:153669515366951537357663Uncultured methanogenic archaeon RC-I, complete genomeconserved GTP-binding protein1e-1272.8
NC_015389:1070500:1097515109751510987831269Coriobacterium glomerans PW2 chromosome, complete genomeiron-only hydrogenase maturation protein HydF1e-0962.8
NC_013156:1182609:120219212021921202839648Methanocaldococcus fervens AG86, complete genomeGTP-binding protein HSR1-related4e-0961.2
NC_016627:1807866:1817674181767418188971224Clostridium clariflavum DSM 19732 chromosome, complete genomehydrogenase maturation GTPase HydF4e-0857.8
NC_018866:1790564:1789329178932917905761248Dehalobacter sp. DCA chromosome, complete genomePutative GTP-binding protein2e-0652
NC_016148:1175999:1178455117845511797681314Thermovirga lienii DSM 17291 chromosome, complete genomeribosome-associated GTPase EngA3e-0651.2