Pre_GI: BLASTP Hits

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Query: NC_004337:3621985:3631741 Shigella flexneri 2a str. 301, complete genome

Start: 3631741, End: 3632271, Length: 531

Host Lineage: Shigella flexneri; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This strain was isolated in 1984 from a patient in Beijing, China. It is similar to pathogenic Escherichia coli except for the more numerous insertion sequences and contains a virulence plasmid (pCP301). Causes enteric disease. Shigella This genus is named for the Japanese scientist (Shiga) who discovered them in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, and over 1 million deaths worldwide are attributed to them. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. are extremely virulent organisms that require very few cells in order to cause disease. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This organism, along with Shigella sonnei, is the major cause of shigellosis in industrialized countries and is responsible for endemic infections.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017328:3655876:366659736665973667127531Shigella flexneri 2002017 chromosome, complete genomeHTH-type transcriptional regulator dctR1e-98358
NC_008258:3581583:359200235920023592532531Shigella flexneri 5 str. 8401, complete genomehypothetical protein1e-98358
NC_004337:3590323:363174136317413632271531Shigella flexneri 2a str. 301, complete genomehypothetical protein1e-98358
NC_007384:3741708:375002237500223750552531Shigella sonnei Ss046, complete genomehypothetical protein1e-98358
NC_004741:4132056:414157741415774142107531Shigella flexneri 2a str. 2457T, complete genomehypothetical protein1e-98358
NC_013361:4566779:457545245754524575982531Escherichia coli O26:H11 str. 11368 chromosome, complete genomeDNA-binding transcriptional regulator1e-98358
NC_013364:4306000:431417243141724314702531Escherichia coli O111:H- str. 11128, complete genomeputative DNA-binding transcriptional regulator1e-98358
NC_016822:3946500:395872139587213959251531Shigella sonnei 53G, complete genomeputative DNA-binding transcriptional regulator1e-98358
NC_011415:3887997:389982538998253900355531Escherichia coli SE11 chromosome, complete genomeputative transcriptional regulator2e-98357
AP010958:4313462:432189343218934322423531Escherichia coli O103:H2 str. 12009 DNA, complete genomepredicted DNA-binding transcriptional regulator1e-97355
CP002185:3822470:385046238504623850992531Escherichia coli W, complete genomepredicted DNA-binding transcriptional regulator1e-97355
CU928145:3983432:401979140197914020321531Escherichia coli 55989 chromosome, complete genomeputative DNA-binding transcriptional regulator1e-97355
CP002516:246767:255081255081255611531Escherichia coli KO11, complete genomeregulatory protein LuxR1e-97355
AC_000091:3976888:398520239852023985732531Escherichia coli W3110 DNA, complete genomepredicted DNA-binding ranscriptional regulator1e-97355
NC_000913:3624826:365270636527063653236531Escherichia coli K12, complete genomepredicted DNA-binding ranscriptional regulator1e-97355
NC_010473:3722571:375045137504513750981531Escherichia coli str. K-12 substr. DH10B, complete genomepredicted DNA-binding ranscriptional regulator1e-97355
NC_009800:3685651:369599436959943696524531Escherichia coli HS, complete genometranscriptional regulator DctR1e-97355
NC_011748:3983432:401979140197914020321531Escherichia coli 55989, complete genomeputative DNA-binding transcriptional regulator1e-97355
NC_009801:3956917:396649439664943967024531Escherichia coli E24377A, complete genometranscriptional regulator DctR1e-97355
NC_016902:246767:255081255081255611531Escherichia coli KO11FL chromosome, complete genomeregulatory protein LuxR1e-97355
NC_013353:4313462:432189343218934322423531Escherichia coli O103:H2 str. 12009, complete genomeDNA-binding transcriptional regulator1e-97355
NC_012967:3549880:358417435841743584704531Escherichia coli B str. REL606 chromosome, complete genomeputative DNA-binding ranscriptional regulator1e-97355
NC_012947:248000:256472256472257002531Escherichia coli 'BL21-Gold(DE3)pLysS AG' chromosome, completeLuxR family transcriptional regulator1e-97355
NC_012759:3529657:354120035412003541730531Escherichia coli BW2952 chromosome, complete genomeputative DNA-binding ranscriptional regulator1e-97355
NC_011741:3709081:371866837186683719198531Escherichia coli IAI1 chromosome, complete genomeputative DNA-binding transcriptional regulator1e-97355
NC_010468:231000:239442239442239972531Escherichia coli ATCC 8739, complete genometranscriptional regulator, LuxR family1e-97355
CU928160:3709081:371866837186683719198531Escherichia coli IAI1 chromosome, complete genomeputative DNA-binding transcriptional regulator1e-97355
NC_007613:3470314:350024935002493500779531Shigella boydii Sb227, complete genomehypothetical protein1e-96351
NC_010658:3622610:363248636324863633016531Shigella boydii CDC 3083-94, complete genometranscriptional regulator DctR1e-96351
NC_010498:3838419:386630638663063866836531Escherichia coli SMS-3-5, complete genometranscriptional regulator DctR2e-96350
NC_010473:3722571:375413437541343754661528Escherichia coli str. K-12 substr. DH10B, complete genomeacid-induced positive regulator of glutamate-dependent acid resistance3e-1167.8
NC_009800:3685651:369967736996773700204528Escherichia coli HS, complete genometranscriptional regulator GadE3e-1167.8
AC_000091:3976888:398152239815223982049528Escherichia coli W3110 DNA, complete genomeDNA-binding transcriptional activator3e-1167.8
NC_008258:3581583:359568435956843596211528Shigella flexneri 5 str. 8401, complete genomehypothetical protein3e-1167.8
NC_000913:3624826:365638936563893656916528Escherichia coli K12, complete genomeDNA-binding transcriptional activator3e-1167.8
CP002185:3822470:385414538541453854672528Escherichia coli W, complete genomeDNA-binding transcriptional activator3e-1167.8
CP002516:246767:251401251401251928528Escherichia coli KO11, complete genomehypothetical protein3e-1167.8
NC_011748:3983432:402347440234744024001528Escherichia coli 55989, complete genomeDNA-binding transcriptional activator3e-1167.8
CU928160:3709081:372235137223513722878528Escherichia coli IAI1 chromosome, complete genomeDNA-binding transcriptional activator3e-1167.8
NC_004337:3590323:363542336354233635950528Shigella flexneri 2a str. 301, complete genomehypothetical protein3e-1167.8
NC_004337:3621985:363542336354233635950528Shigella flexneri 2a str. 301, complete genomehypothetical protein3e-1167.8
AP010958:4313462:432557643255764326103528Escherichia coli O103:H2 str. 12009 DNA, complete genomeDNA-binding transcriptional activator GadE3e-1167.8
CU928145:3983432:402347440234744024001528Escherichia coli 55989 chromosome, complete genomeDNA-binding transcriptional activator3e-1167.8
NC_007384:3741708:374634237463423746869528Shigella sonnei Ss046, complete genomehypothetical protein3e-1167.8
NC_009801:3956917:397017739701773970704528Escherichia coli E24377A, complete genometranscriptional regulator GadE3e-1167.8
NC_017328:3655876:367027936702793670806528Shigella flexneri 2002017 chromosome, complete genomeTranscriptional regulator gadE3e-1167.8
NC_016902:246767:251401251401251928528Escherichia coli KO11FL chromosome, complete genomehypothetical protein3e-1167.8
NC_016822:3946500:396240439624043962931528Shigella sonnei 53G, complete genomeDNA-binding transcriptional activator3e-1167.8
NC_013364:4306000:431785543178554318382528Escherichia coli O111:H- str. 11128, complete genomeDNA-binding transcriptional activator GadE3e-1167.8
NC_013361:4566779:457913545791354579662528Escherichia coli O26:H11 str. 11368 chromosome, complete genomeDNA-binding transcriptional activator GadE3e-1167.8
NC_013353:4313462:432557643255764326103528Escherichia coli O103:H2 str. 12009, complete genomeDNA-binding transcriptional activator GadE3e-1167.8
NC_012967:3549880:358785735878573588384528Escherichia coli B str. REL606 chromosome, complete genomeDNA-binding transcriptional activator3e-1167.8
NC_012947:248000:252792252792253319528Escherichia coli 'BL21-Gold(DE3)pLysS AG' chromosome, completeLuxR family transcriptional regulator3e-1167.8
NC_012759:3529657:354488335448833545410528Escherichia coli BW2952 chromosome, complete genomeDNA-binding transcriptional activator3e-1167.8
NC_011741:3709081:372235137223513722878528Escherichia coli IAI1 chromosome, complete genomeDNA-binding transcriptional activator3e-1167.8
NC_011415:3887997:390350839035083904035528Escherichia coli SE11 chromosome, complete genomehypothetical protein3e-1167.8
NC_004741:4132056:413789841378984138425528Shigella flexneri 2a str. 2457T, complete genomehypothetical protein3e-1167.8
NC_010468:231000:235762235762236289528Escherichia coli ATCC 8739, complete genometranscriptional regulator, LuxR family3e-1167.8
NC_010658:3622610:363616936361693636696528Shigella boydii CDC 3083-94, complete genometranscriptional regulator GadE9e-1166.2
NC_007613:3470314:350393235039323504459528Shigella boydii Sb227, complete genomehypothetical protein9e-1166.2