Pre_GI: BLASTP Hits

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Query: NC_004337:3621985:3629549 Shigella flexneri 2a str. 301, complete genome

Start: 3629549, End: 3630772, Length: 1224

Host Lineage: Shigella flexneri; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This strain was isolated in 1984 from a patient in Beijing, China. It is similar to pathogenic Escherichia coli except for the more numerous insertion sequences and contains a virulence plasmid (pCP301). Causes enteric disease. Shigella This genus is named for the Japanese scientist (Shiga) who discovered them in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, and over 1 million deaths worldwide are attributed to them. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. are extremely virulent organisms that require very few cells in order to cause disease. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This organism, along with Shigella sonnei, is the major cause of shigellosis in industrialized countries and is responsible for endemic infections.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017328:3655876:3664405366440536656281224Shigella flexneri 2002017 chromosome, complete genomehypothetical protein0826
NC_004337:3590323:3629549362954936307721224Shigella flexneri 2a str. 301, complete genomehypothetical protein0826
NC_008258:3581583:3589810358981035910331224Shigella flexneri 5 str. 8401, complete genomehypothetical protein0824
NC_011741:3709081:3716476371647637176991224Escherichia coli IAI1 chromosome, complete genomehypothetical protein0813
CU928160:3709081:3716476371647637176991224Escherichia coli IAI1 chromosome, complete genomeconserved hypothetical protein0813
NC_010498:3838419:3864118386411838653411224Escherichia coli SMS-3-5, complete genomehypothetical protein0651
NC_010468:231000:2409422409422421651224Escherichia coli ATCC 8739, complete genomehypothetical protein0640
NC_012947:248000:2579722579722591951224Escherichia coli 'BL21-Gold(DE3)pLysS AG' chromosome, completehypothetical protein0639
NC_012967:3549880:3581981358198135832041224Escherichia coli B str. REL606 chromosome, complete genomehypothetical protein0639
NC_009800:3685651:3693802369380236949171116Escherichia coli HS, complete genomehypothetical protein2e-160565
NC_011748:3983432:4017600401760040187451146Escherichia coli 55989, complete genomehypothetical protein5e-158557
CU928145:3983432:4017600401760040187451146Escherichia coli 55989 chromosome, complete genomeconserved hypothetical protein5e-158557
NC_011415:3887997:389763738976373898482846Escherichia coli SE11 chromosome, complete genomehypothetical protein5e-119427
CP002516:246767:2565802565802578021223Escherichia coli KO11, complete genome2e-118426
NC_007613:3470314:349805534980553498849795Shigella boydii Sb227, complete genomehypothetical protein2e-118426
AP010958:4313462:431970243197024320547846Escherichia coli O103:H2 str. 12009 DNA, complete genome3e-118425
CP002185:3822470:384827138482713849116846Escherichia coli W, complete genomeconserved hypothetical protein3e-118425
NC_009801:3956917:396430339643033965148846Escherichia coli E24377A, complete genomehypothetical protein3e-118425
NC_013353:4313462:431970243197024320547846Escherichia coli O103:H2 str. 12009, complete genome3e-118425
NC_016822:3946500:395575239557523956597846Shigella sonnei 53G, complete genomehypothetical protein2e-113409
NC_007384:3741708:375267637526763753521846Shigella sonnei Ss046, complete genomehypothetical protein2e-113409
NC_000913:3624826:364931436493143650096783Escherichia coli K12, complete genomehypothetical protein2e-112405
AC_000091:3976888:398834239883423989124783Escherichia coli W3110 DNA, complete genomehypothetical protein2e-112405
NC_010473:3722571:374705937470593747841783Escherichia coli str. K-12 substr. DH10B, complete genomehypothetical protein2e-112405
NC_004741:4132056:414370641437064144299594Shigella flexneri 2a str. 2457T, complete genome8e-109394
NC_013361:4566779:457352145735214574105585Escherichia coli O26:H11 str. 11368 chromosome, complete genome9e-64244
NC_013364:4306000:431198043119804312294315Escherichia coli O111:H- str. 11128, complete genome4e-48192
NC_013364:4306000:431246643124664312825360Escherichia coli O111:H- str. 11128, complete genome7e-31135
NC_013364:4306000:431302043130204313202183Escherichia coli O111:H- str. 11128, complete genome6e-1995.5
NC_013361:4566779:457430045743004574482183Escherichia coli O26:H11 str. 11368 chromosome, complete genome6e-1995.5
NC_011415:3887997:389867738986773898859183Escherichia coli SE11 chromosome, complete genomehypothetical protein6e-1995.5
NC_009801:3956917:396534339653433965525183Escherichia coli E24377A, complete genomehypothetical protein6e-1995.5
NC_010658:3622610:363133336313333631515183Shigella boydii CDC 3083-94, complete genome2e-1894.4