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Query: NC_004088:3689000:3716794 Yersinia pestis KIM, complete genome

Start: 3716794, End: 3717189, Length: 396

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017265:809943:820160820160820555396Yersinia pestis biovar Medievalis str. Harbin 35 chromosome,putative lipoprotein1e-69261
NC_017168:3286:161921619216587396Yersinia pestis A1122 chromosome, complete genomeputative lipoprotein1e-69261
NC_017154:902739:913896913896914291396Yersinia pestis D106004 chromosome, complete genomeputative lipoprotein1e-69261
NC_009381:588137:598342598342598737396Yersinia pestis Pestoides F chromosome, complete genomeputative lipoprotein1e-69261
NC_005810:3917254:393015639301563930551396Yersinia pestis biovar Microtus str. 91001, complete genomeputative lipoprotein1e-69261
NC_008150:317903:329059329059329454396Yersinia pestis Antiqua, complete genomeputative lipoprotein1e-69261
NC_003143:1059580:108868710886871089082396Yersinia pestis CO92, complete genomeputative lipoprotein1e-69261
NC_009708:874770:884985884985885380396Yersinia pseudotuberculosis IP 31758 chromosome, complete genomelipoprotein7e-69258
NC_006155:3805640:383477638347763835171396Yersinia pseudotuberculosis IP 32953, complete genomeputative lipoprotein3e-68256
NC_010634:3720214:374784837478483748177330Yersinia pseudotuberculosis PB1/+, complete genomelipoprotein7e-57218
NC_010465:893921:904188904188904517330Yersinia pseudotuberculosis YPIII, complete genomelipoprotein7e-57218
NC_008149:3556999:358467135846713585000330Yersinia pestis Nepal516, complete genomelipoprotein7e-57218
NC_009708:915814:946425946425946817393Yersinia pseudotuberculosis IP 31758 chromosome, complete genomelipoprotein6e-54209
NC_006155:1756000:178909017890901789482393Yersinia pseudotuberculosis IP 32953, complete genomeputative lipoprotein6e-54209
NC_010634:1755548:178938417893841789713330Yersinia pseudotuberculosis PB1/+, complete genomeputative lipoprotein2e-46184
NC_010159:172469:190380190380190568189Yersinia pestis Angola, complete genomeputative lipoprotein9e-29125