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Query: NC_004088:3689000:3715918 Yersinia pestis KIM, complete genome

Start: 3715918, End: 3716289, Length: 372

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017265:809943:821060821060821431372Yersinia pestis biovar Medievalis str. Harbin 35 chromosome,hypothetical protein8e-56215
NC_017168:3286:170921709217463372Yersinia pestis A1122 chromosome, complete genomehypothetical protein8e-56215
NC_005810:3917254:393105639310563931427372Yersinia pestis biovar Microtus str. 91001, complete genomehypothetical protein8e-56215
NC_008149:3556999:358379535837953584166372Yersinia pestis Nepal516, complete genomehypothetical protein8e-56215
NC_010634:3720214:374698937469893747360372Yersinia pseudotuberculosis PB1/+, complete genomehypothetical protein7e-55212
NC_010465:893921:905005905005905376372Yersinia pseudotuberculosis YPIII, complete genomehypothetical protein4e-54209
NC_003143:1059580:108781110878111088155345Yersinia pestis CO92, complete genomeputative phage protein (partial)3e-50196