Pre_GI: BLASTP Hits

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Query: NC_004088:3689000:3700005 Yersinia pestis KIM, complete genome

Start: 3700005, End: 3700394, Length: 390

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017265:809943:836955836955837344390Yersinia pestis biovar Medievalis str. Harbin 35 chromosome,hypothetical protein2e-64244
NC_003143:1059580:107190710719071072287381Yersinia pestis CO92, complete genomehypothetical protein3e-63239
NC_005810:3917254:394684739468473947347501Yersinia pestis biovar Microtus str. 91001, complete genomehypothetical protein1e-61234
NC_006155:3805640:381798638179863818486501Yersinia pseudotuberculosis IP 32953, complete genomehypothetical protein1e-61234
NC_010634:3720214:373105837310583731567510Yersinia pseudotuberculosis PB1/+, complete genomehypothetical protein4e-60229
NC_011149:2179592:218967321896732190170498Salmonella enterica subsp. enterica serovar Agona str. SL483,hypothetical protein7e-39159
NC_006511:792543:806520806520806984465Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCChypothetical protein6e-39159
NC_011147:792489:806466806466806930465Salmonella enterica subsp. enterica serovar Paratyphi A strhypothetical protein6e-39159
NC_003198:2179688:218976821897682190217450Salmonella enterica subsp. enterica serovar Typhi str. CT18,hypothetical protein9e-37152
NC_004631:799810:813719813719814168450Salmonella enterica subsp. enterica serovar Typhi Ty2, completehypothetical protein9e-37152