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Query: NC_004088:3689000:3699010 Yersinia pestis KIM, complete genome

Start: 3699010, End: 3699267, Length: 258

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_009788:16360:241412414124494354Escherichia coli E24377A plasmid pETEC_73, complete sequence9e-0752.4
NC_006155:3805640:381700138170013817258258Yersinia pseudotuberculosis IP 32953, complete genome3e-45179
NC_006155:3805640:381189838118983812266369Yersinia pseudotuberculosis IP 32953, complete genome3e-22103
NC_014228:1929665:197670019767001977017318Xenorhabdus nematophila ATCC 19061, complete genomeInsertion element IS1 1/5/6 protein insB (fragment)5e-1063.2
NC_003143:1059580:106582910658291066185357Yersinia pestis CO92, complete genomeinsertion sequence protein1e-22105
NC_008149:3556999:356173335617333562101369Yersinia pestis Nepal516, complete genomeinsertion sequence protein1e-22105
NC_017160:1628500:166375916637591664115357Yersinia pestis D182038 chromosome, complete genomeinsertion sequence protein1e-22105
NC_017168:3286:390773907739445369Yersinia pestis A1122 chromosome, complete genomeinsertion sequence protein1e-22105
NC_010159:172469:172469172469172825357Yersinia pestis Angola, complete genomeIS1 family transposase orfB1e-22105
NC_010634:3720214:372494937249493725317369Yersinia pseudotuberculosis PB1/+, complete genomeIS1 transposase3e-22103
NC_020260:882307:912033912033912536504Cronobacter sakazakii Sp291, complete genomeIS1 Transposase4e-0650.4
NC_009649:16907:418314183142334504Klebsiella pneumoniae subsp. pneumoniae MGH 78578 plasmid pKPN3,IS1 transposase4e-0650.4
NC_014107:171170:178865178865179242378Enterobacter cloacae subsp. cloacae ATCC 13047 plasmid pECL_A,IS1 transposase orfB3e-0650.4
NC_014121:3553809:355802135580213558398378Enterobacter cloacae subsp. cloacae ATCC 13047 chromosome, completeIS1 transposase orfB3e-0650.4
NC_008150:317903:346971346971347228258Yersinia pestis Antiqua, complete genomeputative transposase3e-45179
NC_004088:3689000:369390736939073694275369Yersinia pestis KIM, complete genometransposase1e-22105