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Query: NC_004088:3689000:3698934 Yersinia pestis KIM, complete genome

Start: 3698934, End: 3699269, Length: 336

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017265:809943:838100838100838435336Yersinia pestis biovar Medievalis str. Harbin 35 chromosome,Insertion sequence protein1e-60231
NC_006155:3805640:381692538169253817260336Yersinia pseudotuberculosis IP 32953, complete genome1e-60231
NC_005810:3917254:394808339480833948418336Yersinia pestis biovar Microtus str. 91001, complete genome1e-60231
NC_003143:1059580:107085910708591071191333Yersinia pestis CO92, complete genomeinsertion sequence protein (partial)5e-60229
NC_010634:3720214:372494937249493725317369Yersinia pseudotuberculosis PB1/+, complete genomeIS1 transposase1e-1581.6
NC_006155:3805640:381189838118983812266369Yersinia pseudotuberculosis IP 32953, complete genome1e-1581.6
NC_008149:3556999:356173335617333562101369Yersinia pestis Nepal516, complete genomeinsertion sequence protein1e-1478.6
NC_004088:3689000:369390736939073694275369Yersinia pestis KIM, complete genometransposase1e-1478.6
NC_017168:3286:390773907739445369Yersinia pestis A1122 chromosome, complete genomeinsertion sequence protein1e-1478.6
NC_017160:1628500:166375916637591664115357Yersinia pestis D182038 chromosome, complete genomeinsertion sequence protein5e-1269.7
NC_003143:1059580:106582910658291066185357Yersinia pestis CO92, complete genomeinsertion sequence protein5e-1269.7
NC_010159:172469:172469172469172825357Yersinia pestis Angola, complete genomeIS1 family transposase orfB5e-1269.7