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Query: NC_004088:3661601:3675388 Yersinia pestis KIM, complete genome

Start: 3675388, End: 3675618, Length: 231

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_010465:933488:940337940337941071735Yersinia pseudotuberculosis YPIII, complete genomehypothetical protein2e-37154
NC_009708:986918:993873993873994607735Yersinia pseudotuberculosis IP 31758 chromosome, complete genomehypothetical protein2e-37154
NC_009381:627685:634928634928635173246Yersinia pestis Pestoides F chromosome, complete genomehypothetical protein9e-37152
NC_008149:3529428:354321435432143543459246Yersinia pestis Nepal516, complete genomehypothetical protein9e-37152
NC_008150:361224:370587370587370832246Yersinia pestis Antiqua, complete genomehypothetical protein9e-37152
NC_006155:3779381:379313237931323793890759Yersinia pseudotuberculosis IP 32953, complete genomehypothetical protein4e-36149
NC_010634:3692321:370611437061143706848735Yersinia pseudotuberculosis PB1/+, complete genomehypothetical protein4e-36149
NC_017168:50391:577675776757964198Yersinia pestis A1122 chromosome, complete genomehypothetical protein2e-30130
NC_016818:3851542:385154238515423852276735Rahnella aquatilis CIP 78.65 = ATCC 33071 chromosome, completehypothetical protein7e-23105
NC_012779:261438:281199281199281927729Edwardsiella ictaluri 93-146, complete genomehypothetical protein3e-1993.6
NC_013508:275081:298170298170298901732Edwardsiella tarda EIB202, complete genomehypothetical protein5e-1992.8
NC_020418:1397112:142313314231331423861729Morganella morganii subsp. morganii KT, complete genomePutative protein YggN2e-1374.3