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Query: NC_004088:3505383:3532804 Yersinia pestis KIM, complete genome

Start: 3532804, End: 3535917, Length: 3114

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017265:1000342:1001469100146910045823114Yersinia pestis biovar Medievalis str. Harbin 35 chromosome,hypothetical protein02092
NC_008150:513783:5149075149075180203114Yersinia pestis Antiqua, complete genomehypothetical protein02092
NC_008149:3373229:3400642340064234037553114Yersinia pestis Nepal516, complete genomehypothetical protein02092
NC_003143:875367:9027809027809058933114Yersinia pestis CO92, complete genomehypothetical protein02092
NC_009381:775357:7753577753577784703114Yersinia pestis Pestoides F chromosome, complete genomehypothetical protein02092
NC_017168:199381:1993811993812024943114Yersinia pestis A1122 chromosome, complete genomehypothetical protein02092
NC_005810:3142384:3143511314351131466243114Yersinia pestis biovar Microtus str. 91001, complete genomehypothetical protein02090
NC_006155:3596120:3623545362354536266583114Yersinia pseudotuberculosis IP 32953, complete genomepossible chondroitin ABC lyase.02088
NC_010634:3509880:3537305353730535404183114Yersinia pseudotuberculosis PB1/+, complete genomelyase catalytic02080
NC_014029:1146900:1148024114802411510983075Yersinia pestis Z176003 chromosome, complete genomehypothetical protein02078
NC_017154:1089044:1090168109016810932423075Yersinia pestis D106004 chromosome, complete genomehypothetical protein02078
NC_017160:1092839:1092839109283910959133075Yersinia pestis D182038 chromosome, complete genomehypothetical protein02078
NC_010159:3448490:3476966347696634800403075Yersinia pestis Angola, complete genomepolysaccharide lyase, family 802076
NC_010465:1118147:1119977111997711230513075Yersinia pseudotuberculosis YPIII, complete genomeLyase catalytic02070
NC_009708:1131500:1131522113152211345963075Yersinia pseudotuberculosis IP 31758 chromosome, complete genomepolysaccharide lyase family protein 802063
NC_010067:2304313:2307695230769523108083114Salmonella enterica subsp. arizonae serovar 62:z4,z23:--, completehypothetical protein01715
NC_012779:3176820:3176820317682031798883069Edwardsiella ictaluri 93-146, complete genomechondroitin ABC endolyase 101083
NC_012779:3176820:3179954317995431830013048Edwardsiella ictaluri 93-146, complete genomehypothetical protein3e-93343
NC_013201:4500:80108010114053396Halomicrobium mukohataei DSM 12286 plasmid pHmuk01, completeHyaluronate lyase9e-0860.1