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Query: NC_004088:3505383:3529483 Yersinia pestis KIM, complete genome

Start: 3529483, End: 3530433, Length: 951

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017265:1000342:100695310069531007903951Yersinia pestis biovar Medievalis str. Harbin 35 chromosome,hypothetical protein0655
NC_010159:3448490:347360634736063474556951Yersinia pestis Angola, complete genomehypothetical protein0655
NC_010465:1118147:112546111254611126411951Yersinia pseudotuberculosis YPIII, complete genomehypothetical protein0655
NC_008150:513783:520391520391521341951Yersinia pestis Antiqua, complete genomehypothetical protein0655
NC_006155:3596120:362022436202243621174951Yersinia pseudotuberculosis IP 32953, complete genomehypothetical protein0655
NC_005810:3142384:314899531489953149945951Yersinia pestis biovar Microtus str. 91001, complete genomehypothetical protein0655
NC_003143:875367:899459899459900409951Yersinia pestis CO92, complete genomehypothetical protein0655
NC_010634:3509880:353398435339843534934951Yersinia pseudotuberculosis PB1/+, complete genomehypothetical protein0655
NC_008149:3373229:339732133973213398271951Yersinia pestis Nepal516, complete genomehypothetical protein0655
NC_009381:775357:780840780840781790951Yersinia pestis Pestoides F chromosome, complete genomehypothetical protein0655
NC_009708:1131500:113700611370061137956951Yersinia pseudotuberculosis IP 31758 chromosome, complete genomehypothetical protein0655
NC_014029:1146900:115350811535081154458951Yersinia pestis Z176003 chromosome, complete genomehypothetical protein0655
NC_017154:1089044:109565210956521096602951Yersinia pestis D106004 chromosome, complete genomehypothetical protein0655
NC_017160:1092839:109832510983251099275951Yersinia pestis D182038 chromosome, complete genomehypothetical protein0655
NC_017168:199381:204865204865205815951Yersinia pestis A1122 chromosome, complete genomehypothetical protein0655
NC_010067:2304313:230431323043132305242930Salmonella enterica subsp. arizonae serovar 62:z4,z23:--, completehypothetical protein3e-148524