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Query: NC_004088:3505383:3528572 Yersinia pestis KIM, complete genome

Start: 3528572, End: 3528880, Length: 309

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017168:199381:206418206418206726309Yersinia pestis A1122 chromosome, complete genomehypothetical protein2e-56217
NC_009381:775357:782393782393782701309Yersinia pestis Pestoides F chromosome, complete genomehypothetical protein2e-56217
NC_008150:513783:521944521944522252309Yersinia pestis Antiqua, complete genomehypothetical protein2e-56217
NC_003143:875367:898548898548898856309Yersinia pestis CO92, complete genomehypothetical protein2e-56217
NC_008149:3373229:339641033964103396718309Yersinia pestis Nepal516, complete genomehypothetical protein2e-56217
NC_005810:3142384:315055031505503150858309Yersinia pestis biovar Microtus str. 91001, complete genomehypothetical protein2e-56217
NC_006155:3596120:361926236192623619621360Yersinia pseudotuberculosis IP 32953, complete genomehypothetical protein2e-48190
NC_017265:1000342:100850610085061008694189Yersinia pestis biovar Medievalis str. Harbin 35 chromosome,hypothetical protein1e-31134
NC_010159:3448490:347281534728153473003189Yersinia pestis Angola, complete genome1e-31134
NC_009708:1131500:113855911385591138747189Yersinia pseudotuberculosis IP 31758 chromosome, complete genomehypothetical protein4e-30129
NC_010634:3509880:353319335331933533381189Yersinia pseudotuberculosis PB1/+, complete genomehypothetical protein4e-30129
NC_010465:1118147:112701411270141127202189Yersinia pseudotuberculosis YPIII, complete genomehypothetical protein4e-30129