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Query: NC_004088:3505383:3526282 Yersinia pestis KIM, complete genome

Start: 3526282, End: 3526698, Length: 417

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017265:1000342:101068810106881011104417Yersinia pestis biovar Medievalis str. Harbin 35 chromosome,hypothetical protein3e-76283
NC_005810:3142384:315273231527323153148417Yersinia pestis biovar Microtus str. 91001, complete genomehypothetical protein3e-76283
NC_008150:513783:524126524126524542417Yersinia pestis Antiqua, complete genomehypothetical protein3e-76283
NC_008149:3373229:339412033941203394536417Yersinia pestis Nepal516, complete genomehypothetical protein3e-76283
NC_010465:1118147:112919611291961129612417Yersinia pseudotuberculosis YPIII, complete genomeputative transcriptional regulator, CadC3e-76283
NC_006155:3596120:361702436170243617440417Yersinia pseudotuberculosis IP 32953, complete genomehypothetical protein3e-76283
NC_003143:875367:896258896258896674417Yersinia pestis CO92, complete genomehypothetical protein3e-76283
NC_010634:3509880:353078435307843531200417Yersinia pseudotuberculosis PB1/+, complete genomeputative transcriptional regulator, CadC3e-76283
NC_009708:1131500:114074011407401141156417Yersinia pseudotuberculosis IP 31758 chromosome, complete genomehypothetical protein3e-76283
NC_014029:1146900:115724311572431157659417Yersinia pestis Z176003 chromosome, complete genomehypothetical protein3e-76283
NC_017154:1089044:109938710993871099803417Yersinia pestis D106004 chromosome, complete genomehypothetical protein3e-76283
NC_017160:1092839:110206011020601102476417Yersinia pestis D182038 chromosome, complete genomehypothetical protein3e-76283
NC_017168:199381:208600208600209016417Yersinia pestis A1122 chromosome, complete genomehypothetical protein3e-76283
NC_015224:1067390:107849910784991078915417Yersinia enterocolitica subsp. palearctica 105.5R(r) chromosome,hypothetical protein2e-66250
NC_008800:3642679:366378836637883664204417Yersinia enterocolitica subsp. enterocolitica 8081 chromosome,hypothetical protein5e-66249
NC_010159:3448490:347048334704833470821339Yersinia pestis Angola, complete genome2e-59227
NC_020064:3998715:406168040616804062153474Serratia marcescens FGI94, complete genomehypothetical protein4e-1373.6
NC_009832:4564752:458945245894524589856405Serratia proteamaculans 568, complete genomeputative transcriptional regulator, CadC5e-0960.1
NC_017328:3088907:314242331424233143028606Shigella flexneri 2002017 chromosome, complete genomeMembrane protein3e-0650.4
NC_004337:3049118:310405631040563104661606Shigella flexneri 2a str. 301, complete genomehypothetical protein3e-0650.4
NC_004741:3041294:309354530935453094150606Shigella flexneri 2a str. 2457T, complete genomehypothetical protein3e-0650.4