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Query: NC_004088:3505383:3516440 Yersinia pestis KIM, complete genome

Start: 3516440, End: 3516901, Length: 462

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017265:1000342:102048510204851020946462Yersinia pestis biovar Medievalis str. Harbin 35 chromosome,hypothetical protein3e-82303
NC_003143:875367:886416886416886877462Yersinia pestis CO92, complete genomehypothetical protein3e-82303
NC_010634:3509880:352094135209413521402462Yersinia pseudotuberculosis PB1/+, complete genomehypothetical protein3e-82303
NC_006155:3596120:360718136071813607642462Yersinia pseudotuberculosis IP 32953, complete genomehypothetical protein3e-82303
NC_008149:3373229:338427833842783384739462Yersinia pestis Nepal516, complete genomemembrane protein3e-82303
NC_010465:1118147:113899611389961139457462Yersinia pseudotuberculosis YPIII, complete genomehypothetical protein3e-82303
NC_008150:513783:533923533923534384462Yersinia pestis Antiqua, complete genomehypothetical protein3e-82303
NC_005810:3142384:316253031625303162991462Yersinia pestis biovar Microtus str. 91001, complete genomehypothetical protein3e-82303
NC_009381:775357:794372794372794833462Yersinia pestis Pestoides F chromosome, complete genomehypothetical protein3e-82303
NC_017168:199381:218397218397218858462Yersinia pestis A1122 chromosome, complete genomehypothetical protein3e-82303
NC_017160:1092839:111186911118691112318450Yersinia pestis D182038 chromosome, complete genomemembrane protein1e-79294
NC_017154:1089044:110919711091971109646450Yersinia pestis D106004 chromosome, complete genomemembrane protein1e-79294
NC_009708:1131500:115053811505381150999462Yersinia pseudotuberculosis IP 31758 chromosome, complete genomehypothetical protein6e-76282
NC_010159:3448490:346055034605503460864315Yersinia pestis Angola, complete genomehypothetical protein3e-40163