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Query: NC_004088:3505383:3513809 Yersinia pestis KIM, complete genome

Start: 3513809, End: 3514285, Length: 477

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017265:1000342:102316810231681023569402Yersinia pestis biovar Medievalis str. Harbin 35 chromosome,hypothetical protein3e-70263
NC_005810:3142384:316652831665283166929402Yersinia pestis biovar Microtus str. 91001, complete genomehypothetical protein3e-70263
NC_003143:875367:883793883793884194402Yersinia pestis CO92, complete genomehypothetical protein3e-70263
NC_008149:3373229:338165533816553382056402Yersinia pestis Nepal516, complete genomehypothetical protein3e-70263
NC_010465:1118147:114167311416731142074402Yersinia pseudotuberculosis YPIII, complete genomehypothetical protein3e-70263
NC_008150:513783:536605536605537006402Yersinia pestis Antiqua, complete genomehypothetical protein3e-70263
NC_017168:199381:221088221088221489402Yersinia pestis A1122 chromosome, complete genomehypothetical protein3e-70263
NC_006155:3596120:360456336045633605036474Yersinia pseudotuberculosis IP 32953, complete genomehypothetical protein6e-70262
NC_010634:3509880:351832335183233518796474Yersinia pseudotuberculosis PB1/+, complete genomehypothetical protein6e-70262
NC_009708:1131500:115321811532181153619402Yersinia pseudotuberculosis IP 31758 chromosome, complete genomehypothetical protein5e-65246
NC_008800:3642679:365215236521523652598447Yersinia enterocolitica subsp. enterocolitica 8081 chromosome,hypothetical protein4e-35147
NC_010159:3448490:345793534579353458111177Yersinia pestis Angola, complete genomehypothetical protein4e-27120
NC_015224:1067390:109057710905771090792216Yersinia enterocolitica subsp. palearctica 105.5R(r) chromosome,hypothetical protein7e-1889.4