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Query: NC_004088:2937077:2959360 Yersinia pestis KIM, complete genome

Start: 2959360, End: 2959551, Length: 192

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017265:2557476:257949725794972579949453Yersinia pestis biovar Medievalis str. Harbin 35 chromosome,hypothetical protein1e-21101
NC_017168:3948514:397053539705353970987453Yersinia pestis A1122 chromosome, complete genomehypothetical protein1e-21101
NC_014029:1760948:176258917625891763041453Yersinia pestis Z176003 chromosome, complete genomehypothetical protein1e-21101
NC_009708:2788855:280954528095452809997453Yersinia pseudotuberculosis IP 31758 chromosome, complete genomehypothetical protein1e-21101
NC_009381:1655731:167642916764291676881453Yersinia pestis Pestoides F chromosome, complete genomehypothetical protein1e-21101
NC_010465:2820500:283999128399912840443453Yersinia pseudotuberculosis YPIII, complete genometype VI secretion system lysozyme-related protein4e-21100
NC_017060:125480:155976155976156407432Rahnella aquatilis HX2 plasmid PRA1, complete sequencetype VI secretion system lysozyme-like protein2e-1581.3
NC_014121:1822895:184423118442311844686456Enterobacter cloacae subsp. cloacae ATCC 13047 chromosome, completetype VI secretion system protein1e-1478.6
NC_014837:3766426:378651337865133786953441Pantoea sp. At-9b chromosome, complete genometype VI secretion system lysozyme-like protein6e-1372.8
NC_011283:2103500:212274421227442123187444Klebsiella pneumoniae 342 chromosome, complete genometype VI secretion system lysozyme-like protein3e-1270.5
NC_016514:1627664:163883616388361639285450Enterobacter cloacae EcWSU1 chromosome, complete genomehypothetical protein3e-1063.9
NC_011742:3057444:306247930624793062907429Escherichia coli S88 chromosome, complete genomehypothetical protein8e-1062.4
NC_007946:3125577:313061231306123131040429Escherichia coli UTI89, complete genomehypothetical protein8e-1062.4
NC_013961:3269368:329308232930823293534453Erwinia amylovora, complete genomeCOG3518: putative type VI secretion system, core protein1e-0962
NC_013971:465318:477848477848478300453Erwinia amylovora ATCC 49946 chromosome, complete genomehypothetical protein1e-0962
NC_008253:2965573:297080029708002971228429Escherichia coli 536, complete genomehypothetical protein1e-0962
NC_010067:2488141:250595125059512506400450Salmonella enterica subsp. arizonae serovar 62:z4,z23:--, completehypothetical protein1e-0962
NC_012962:4427000:443157544315754432009435Photorhabdus asymbiotica, complete genomehypothetical protein3e-0960.5
NC_010067:2488141:251155225115522512001450Salmonella enterica subsp. arizonae serovar 62:z4,z23:--, completehypothetical protein5e-0959.7
NC_011283:942594:942594942594943019426Klebsiella pneumoniae 342 chromosome, complete genometype VI secretion system lysozyme-like protein3e-0857
NC_009648:3476000:349658834965883497013426Klebsiella pneumoniae subsp. pneumoniae MGH 78578, complete genomehypothetical protein3e-0857