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Query: NC_004088:2491303:2509427 Yersinia pestis KIM, complete genome

Start: 2509427, End: 2510020, Length: 594

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_005810:2091930:209193020919302092523594Yersinia pestis biovar Microtus str. 91001, complete genomehypothetical protein4e-105380
NC_008150:1593500:159378815937881594351564Yersinia pestis Antiqua, complete genomeputative lipoprotein4e-98357
NC_006155:2378526:237852623785262379089564Yersinia pseudotuberculosis IP 32953, complete genomeputative lipoprotein4e-98357
NC_003143:2309500:230950023095002310063564Yersinia pestis CO92, complete genomeputative lipoprotein4e-98357
NC_010465:2383219:240132624013262401889564Yersinia pseudotuberculosis YPIII, complete genomeprotein of unknown function DUF14394e-98357
NC_008149:1718000:171811617181161718679564Yersinia pestis Nepal516, complete genomelipoprotein4e-98357
NC_009381:1205900:122397012239701224533564Yersinia pestis Pestoides F chromosome, complete genomehypothetical protein4e-98357
NC_009708:2347350:236422223642222364785564Yersinia pseudotuberculosis IP 31758 chromosome, complete genomehypothetical protein4e-98357
NC_014029:2285323:230344523034452304008564Yersinia pestis Z176003 chromosome, complete genomeputative lipoprotein4e-98357
NC_017154:2306421:230642123064212306984564Yersinia pestis D106004 chromosome, complete genomeputative lipoprotein4e-98357
NC_017160:2212806:223094422309442231507564Yersinia pestis D182038 chromosome, complete genomeputative lipoprotein4e-98357
NC_017168:3433804:345191034519103452473564Yersinia pestis A1122 chromosome, complete genomelipoprotein4e-98357
NC_017265:2213500:223112122311212231684564Yersinia pestis biovar Medievalis str. Harbin 35 chromosome,putative lipoprotein4e-98357
NC_010159:2546590:256474625647462565309564Yersinia pestis Angola, complete genomeputative lipoprotein3e-97354
NC_008800:2592500:261019726101972610760564Yersinia enterocolitica subsp. enterocolitica 8081 chromosome,hypothetical protein4e-94343
NC_017047:1796000:181207418120741812637564Rahnella aquatilis HX2 chromosome, complete genomelipoprotein2e-75281