Pre_GI: BLASTP Hits

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Query: NC_004088:2366000:2382921 Yersinia pestis KIM, complete genome

Start: 2382921, End: 2383211, Length: 291

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017265:2087487:210461821046182104908291Yersinia pestis biovar Medievalis str. Harbin 35 chromosome,hypothetical protein4e-38156
NC_008149:1842500:184561018456101845900291Yersinia pestis Nepal516, complete genomehypothetical protein4e-38156
NC_008150:1705152:170895817089581709248291Yersinia pestis Antiqua, complete genomehypothetical protein4e-38156
NC_003143:2433190:243699624369962437286291Yersinia pestis CO92, complete genomehypothetical protein4e-38156
NC_006155:2461262:246429224642922464582291Yersinia pseudotuberculosis IP 32953, complete genomehypothetical protein4e-38156
NC_005810:2180303:218613721861372186427291Yersinia pestis biovar Microtus str. 91001, complete genomehypothetical protein4e-38156
NC_010159:2440947:245503624550362455326291Yersinia pestis Angola, complete genomehypothetical protein4e-38156
NC_010634:2376245:238210923821092382399291Yersinia pseudotuberculosis PB1/+, complete genomehypothetical protein4e-38156
NC_008800:2448583:246436724643672464657291Yersinia enterocolitica subsp. enterocolitica 8081 chromosome,hypothetical protein6e-32135
NC_015224:2618192:263366426336642633954291Yersinia enterocolitica subsp. palearctica 105.5R(r) chromosome,hypothetical protein3e-31133
NC_013421:2453078:245888524588852459178294Pectobacterium wasabiae WPP163, complete genomeprotein of unknown function DUF14964e-1580.1
NC_014306:2703544:272477527247752725131357Erwinia billingiae Eb661, complete genomeConserved uncharacterized protein1e-0962