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Query: NC_004088:179775:197671 Yersinia pestis KIM, complete genome

Start: 197671, End: 197973, Length: 303

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017265:4171500:418861841886184188920303Yersinia pestis biovar Medievalis str. Harbin 35 chromosome,putative phage-like protein9e-53205
NC_008149:3966586:398448239844823984784303Yersinia pestis Nepal516, complete genomehypothetical protein9e-53205
NC_010634:4150763:416893841689384169240303Yersinia pseudotuberculosis PB1/+, complete genomehypothetical protein9e-53205
NC_005810:4381182:439941943994194399721303Yersinia pestis biovar Microtus str. 91001, complete genomeputative phage-related protein9e-53205
NC_006155:4210606:422879942287994229101303Yersinia pseudotuberculosis IP 32953, complete genomeputative phage-related protein9e-53205
NC_015224:4028150:404432840443284044639312Yersinia enterocolitica subsp. palearctica 105.5R(r) chromosome,putative phage-related protein6e-33139
NC_012962:3933715:393452739345273934835309Photorhabdus asymbiotica, complete genomePutative phage-related protein8e-22102
NC_010159:1208699:122873112287311228865135Yersinia pestis Angola, complete genomeputative phage-related protein3e-1890.1
NC_003143:3583468:358982335898233590128306Yersinia pestis CO92, complete genomehypothetical protein7e-1785.9
NC_005810:754340:768190768190768495306Yersinia pestis biovar Microtus str. 91001, complete genomehypothetical protein7e-1785.9
NC_010634:1056441:107023510702351070540306Yersinia pseudotuberculosis PB1/+, complete genomeputative holin protein7e-1785.9
NC_006155:1074298:108809210880921088397306Yersinia pseudotuberculosis IP 32953, complete genomepossible holin protein7e-1785.9
NC_010465:3597000:360254736025473602852306Yersinia pseudotuberculosis YPIII, complete genomeputative holin protein7e-1785.9
NC_017168:2158839:217183921718392172144306Yersinia pestis A1122 chromosome, complete genomehypothetical protein7e-1785.9
NC_017265:3375463:338145333814533381758306Yersinia pestis biovar Medievalis str. Harbin 35 chromosome,hypothetical protein7e-1785.9
NC_016818:1963875:197534119753411975658318Rahnella aquatilis CIP 78.65 = ATCC 33071 chromosome, completehypothetical protein1e-1168.2