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Query: NC_003997:4745027:4760138 Bacillus anthracis str. Ames, complete genome

Start: 4760138, End: 4760383, Length: 246

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This well studied laboratory strain (Porton isolate) is not virulent due to the loss of the two plasmids, pXO1 and pXO2. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_012659:4745053:476016447601644760409246Bacillus anthracis str. A0248, complete genomehypothetical protein1e-40164
NC_005957:4757215:477103347710334771278246Bacillus thuringiensis serovar konkukian str. 97-27, completehypothetical protein1e-40164
NC_007530:4744870:476026447602644760509246Bacillus anthracis str. 'Ames Ancestor', complete genomehypothetical protein1e-40164
NC_005945:4747740:476147347614734761718246Bacillus anthracis str. Sterne, complete genomehypothetical protein1e-40164
NC_003909:4737882:475112147511214751366246Bacillus cereus ATCC 10987, complete genomehypothetical protein8e-40162
NC_017200:4814000:482689548268954827140246Bacillus thuringiensis serovar finitimus YBT-020 chromosome,hypothetical protein8e-40162
NC_004722:4899940:491249849124984912743246Bacillus cereus ATCC 14579, complete genomeIG hypothetical 170297e-40162
NC_014335:4697293:471304547130454713290246Bacillus cereus biovar anthracis str. CI chromosome, completehypothetical protein7e-40162
NC_011658:4739951:475411247541124754357246Bacillus cereus AH187 chromosome, complete genomehypothetical protein7e-40162
NC_011725:4944072:495675549567554957000246Bacillus cereus B4264 chromosome, complete genomehypothetical protein7e-40162
NC_011773:4807911:482113148211314821376246Bacillus cereus AH820 chromosome, complete genomehypothetical protein7e-40162
NC_011969:4680836:469475446947544694999246Bacillus cereus Q1 chromosome, complete genomehypothetical protein7e-40162
NC_014171:4812340:482502348250234825268246Bacillus thuringiensis BMB171 chromosome, complete genomehypothetical protein7e-40162
NC_016771:4692772:470796947079694708214246Bacillus cereus NC7401, complete genomehypothetical protein7e-40162
NC_006274:4814601:482886048288604829105246Bacillus cereus E33L, complete genomehypothetical protein3e-39160
NC_010184:4791000:480321048032104803455246Bacillus weihenstephanensis KBAB4, complete genomehypothetical protein2e-39160
NC_017208:4996992:501045750104575010702246Bacillus thuringiensis serovar chinensis CT-43 chromosome, completehypothetical protein2e-39160
NC_011772:4875893:490928849092884909533246Bacillus cereus G9842, complete genomehypothetical protein1e-38158
UCMB5137:2894511:289626528962652896507243Bacillus atrophaeus UCMB-5137hypothetical protein4e-23106