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Query: NC_003997:4745027:4757815 Bacillus anthracis str. Ames, complete genome

Start: 4757815, End: 4757961, Length: 147

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This well studied laboratory strain (Porton isolate) is not virulent due to the loss of the two plasmids, pXO1 and pXO2. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017200:4814000:482457148245714824717147Bacillus thuringiensis serovar finitimus YBT-020 chromosome,hypothetical protein2e-2097.4
NC_012659:4745053:475784147578414757987147Bacillus anthracis str. A0248, complete genomehypothetical protein2e-2097.4
NC_011773:4807911:481880748188074818953147Bacillus cereus AH820 chromosome, complete genomehypothetical protein2e-2097.4
NC_003909:4737882:474879747487974748943147Bacillus cereus ATCC 10987, complete genomehypothetical protein2e-2097.4
NC_014335:4697293:471072047107204710866147Bacillus cereus biovar anthracis str. CI chromosome, completehypothetical protein2e-2097.4
NC_007530:4744870:475794147579414758087147Bacillus anthracis str. 'Ames Ancestor', complete genomehypothetical protein2e-2097.4
NC_017208:4996992:500812250081225008268147Bacillus thuringiensis serovar chinensis CT-43 chromosome, completehypothetical protein2e-1890.9
NC_011725:4944072:495443049544304954576147Bacillus cereus B4264 chromosome, complete genomehypothetical protein3e-1890.5
NC_011772:4875893:490695649069564907102147Bacillus cereus G9842, complete genomehypothetical protein3e-1890.5
NC_010184:4791000:480087648008764801022147Bacillus weihenstephanensis KBAB4, complete genomehypothetical protein1e-1788.6
NC_016771:4692772:470549447054944705628135Bacillus cereus NC7401, complete genomehypothetical protein4e-1683.6
NC_011969:4680836:469227946922794692413135Bacillus cereus Q1 chromosome, complete genomehypothetical protein4e-1683.6
NC_011658:4739951:475163747516374751771135Bacillus cereus AH187 chromosome, complete genomehypothetical protein4e-1683.6