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Query: NC_003997:4745027:4748899 Bacillus anthracis str. Ames, complete genome

Start: 4748899, End: 4749084, Length: 186

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This well studied laboratory strain (Porton isolate) is not virulent due to the loss of the two plasmids, pXO1 and pXO2. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017208:4996992:499948349994834999668186Bacillus thuringiensis serovar chinensis CT-43 chromosome, completehypothetical protein7e-29125
NC_007530:4744870:474902547490254749210186Bacillus anthracis str. 'Ames Ancestor', complete genomehypothetical protein7e-29125
NC_005957:4757215:475867247586724758857186Bacillus thuringiensis serovar konkukian str. 97-27, completehypothetical protein7e-29125
NC_011772:4875893:490008049000804900265186Bacillus cereus G9842, complete genomehypothetical protein7e-29125
NC_004722:4899940:490139849013984901583186Bacillus cereus ATCC 14579, complete genomehypothetical protein7e-29125
NC_003909:4737882:473933947393394739524186Bacillus cereus ATCC 10987, complete genomehypothetical protein7e-29125
NC_005945:4747740:475023447502344750419186Bacillus anthracis str. Sterne, complete genomehypothetical protein7e-29125
NC_014335:4697293:470240247024024702587186Bacillus cereus biovar anthracis str. CI chromosome, completehypothetical protein7e-29125
NC_006274:4814601:481709548170954817280186Bacillus cereus E33L, complete genomehypothetical protein7e-29125
NC_011658:4739951:474140947414094741594186Bacillus cereus AH187 chromosome, complete genomehypothetical protein7e-29125
NC_011725:4944072:494553049455304945715186Bacillus cereus B4264 chromosome, complete genomehypothetical protein7e-29125
NC_011773:4807911:480936848093684809553186Bacillus cereus AH820 chromosome, complete genomehypothetical protein7e-29125
NC_011969:4680836:468229546822954682480186Bacillus cereus Q1 chromosome, complete genomehypothetical protein7e-29125
NC_012659:4745053:474892547489254749110186Bacillus anthracis str. A0248, complete genomehypothetical protein7e-29125
NC_014171:4812340:481379848137984813983186Bacillus thuringiensis BMB171 chromosome, complete genomehypothetical protein7e-29125
NC_016771:4692772:469526646952664695451186Bacillus cereus NC7401, complete genomehypothetical protein7e-29125
NC_017200:4814000:481435648143564814541186Bacillus thuringiensis serovar finitimus YBT-020 chromosome,hypothetical protein7e-29125
NC_010184:4791000:479142147914214791606186Bacillus weihenstephanensis KBAB4, complete genomehypothetical protein2e-28124