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Query: NC_003997:4745027:4748637 Bacillus anthracis str. Ames, complete genome

Start: 4748637, End: 4748885, Length: 249

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This well studied laboratory strain (Porton isolate) is not virulent due to the loss of the two plasmids, pXO1 and pXO2. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017200:4814000:481409448140944814342249Bacillus thuringiensis serovar finitimus YBT-020 chromosome,spore coat protein F-related protein4e-41166
NC_014335:4697293:470214047021404702388249Bacillus cereus biovar anthracis str. CI chromosome, completespore coat protein F-related protein4e-41166
NC_005945:4747740:474997247499724750220249Bacillus anthracis str. Sterne, complete genomespore coat protein F-related protein4e-41166
NC_006274:4814601:481683348168334817081249Bacillus cereus E33L, complete genomeconserved hypothetical protein; possible spore coat protein F-related protein4e-41166
NC_007530:4744870:474876347487634749011249Bacillus anthracis str. 'Ames Ancestor', complete genomespore coat protein f-related protein4e-41166
NC_003909:4737882:473907747390774739325249Bacillus cereus ATCC 10987, complete genomespore coat protein F-related protein4e-41166
NC_005957:4757215:475841047584104758658249Bacillus thuringiensis serovar konkukian str. 97-27, completeconserved hypothetical protein, possible spore coat protein F-related protein4e-41166
NC_011658:4739951:474114747411474741395249Bacillus cereus AH187 chromosome, complete genomespore coat protein F-like protein4e-41166
NC_011773:4807911:480910648091064809354249Bacillus cereus AH820 chromosome, complete genomespore coat protein F-related protein4e-41166
NC_011969:4680836:468203346820334682281249Bacillus cereus Q1 chromosome, complete genomehypothetical protein4e-41166
NC_012659:4745053:474866347486634748911249Bacillus anthracis str. A0248, complete genomespore coat protein F-related protein4e-41166
NC_016771:4692772:469500446950044695252249Bacillus cereus NC7401, complete genomespore coat protein F-like protein4e-41166
NC_011772:4875893:489981848998184900066249Bacillus cereus G9842, complete genomespore coat protein F-related protein8e-41165
NC_017208:4996992:499922149992214999469249Bacillus thuringiensis serovar chinensis CT-43 chromosome, completehypothetical protein2e-40164
NC_014171:4812340:481353648135364813784249Bacillus thuringiensis BMB171 chromosome, complete genomehypothetical protein2e-40164
NC_011725:4944072:494526849452684945516249Bacillus cereus B4264 chromosome, complete genomespore coat protein F-related protein2e-40164
NC_004722:4899940:490113649011364901384249Bacillus cereus ATCC 14579, complete genomehypothetical protein2e-40164
NC_010184:4791000:479115947911594791407249Bacillus weihenstephanensis KBAB4, complete genomeCoat F domain protein1e-39161