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Query: NC_003997:4745027:4746405 Bacillus anthracis str. Ames, complete genome

Start: 4746405, End: 4747418, Length: 1014

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This well studied laboratory strain (Porton isolate) is not virulent due to the loss of the two plasmids, pXO1 and pXO2. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_012659:4745053:4746431474643147474441014Bacillus anthracis str. A0248, complete genomehypothetical protein5e-162570
NC_005945:4747740:4747740474774047487531014Bacillus anthracis str. Sterne, complete genomehypothetical protein5e-162570
NC_007530:4744870:4746531474653147475441014Bacillus anthracis str. 'Ames Ancestor', complete genomehypothetical protein5e-162570
NC_016771:4692772:4692772469277246937851014Bacillus cereus NC7401, complete genomehypothetical protein8e-162569
NC_014335:4697293:4699907469990747009201014Bacillus cereus biovar anthracis str. CI chromosome, completehypothetical protein8e-162569
NC_011772:4875893:4897586489758648985991014Bacillus cereus G9842, complete genomehypothetical protein2e-161568
NC_006274:4814601:4814601481460148156141014Bacillus cereus E33L, complete genomeconserved hypothetical protein; possible regulatory protein4e-161567
NC_009922:1:1691116911179571047Alkaliphilus oremlandii OhILAs, complete genomephosphotransferase system, EIIC3e-44179
NC_003454:370418:388384388384389376993Fusobacterium nucleatum subsp. nucleatum ATCC 25586, completepfoS/R2e-37157
NC_015275:1223088:1222000122200012230911092Clostridium lentocellum DSM 5427 chromosome, complete genomephosphotransferase system, EIIC5e-33142
NC_010610:1649500:1651474165147416525681095Lactobacillus fermentum IFO 3956, complete genomehypothetical protein5e-31135
NC_010718:2265447:2274204227420422752441041Natranaerobius thermophilus JW/NM-WN-LF, complete genomeputative PTS system, EIIc component1e-28127
NC_015519:426948:4473814473814484721092Tepidanaerobacter sp. Re1 chromosome, complete genomephosphotransferase system EIIC7e-23108
NC_014632:113420:1189431189431199891047Ilyobacter polytropus DSM 2926 chromosome, complete genomeputative PTS system, EIIC component4e-1892.4
NC_014727:368698:3897363897363907911056Lactobacillus delbrueckii subsp. bulgaricus ND02 chromosome,membrane protein, toxin regulator3e-0859.7
NC_015601:1463500:1477936147793614789851050Erysipelothrix rhusiopathiae str. Fujisawa, complete genomeputative regulatory protein5e-0858.9
NC_008528:331260:350929350929351894966Oenococcus oeni PSU-1, complete genomePredicted membrane protein, putative toxin regulator8e-0755.1