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Query: NC_003997:4745027:4745701 Bacillus anthracis str. Ames, complete genome

Start: 4745701, End: 4746348, Length: 648

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This well studied laboratory strain (Porton isolate) is not virulent due to the loss of the two plasmids, pXO1 and pXO2. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_012659:4745053:474572747457274746374648Bacillus anthracis str. A0248, complete genomePAP2 family protein7e-98356
NC_007530:4744870:474582747458274746474648Bacillus anthracis str. 'Ames Ancestor', complete genomepap2 family protein7e-98356
NC_014335:4697293:469920246992024699849648Bacillus cereus biovar anthracis str. CI chromosome, completehypothetical protein2e-96351
NC_011772:4875893:489687948968794897526648Bacillus cereus G9842, complete genomePAP2 family protein2e-93341
NC_014328:1263139:127655312765531277203651Clostridium ljungdahlii ATCC 49587 chromosome, complete genomehypothetical protein2e-36151
NC_010376:28812:288122881229450639Finegoldia magna ATCC 29328, complete genomeSer/Thr and Tyr protein phosphatase7e-1063.9
NC_014246:1787154:180309618030961803731636Mobiluncus curtisii ATCC 43063 chromosome, complete genomeSer/Thr and Tyr protein phosphatase (dual specificity)2e-0755.8
NC_016514:2647984:267403126740312674660630Enterobacter cloacae EcWSU1 chromosome, complete genomehypothetical protein4e-0754.7
NC_015636:1603664:161616216161621616848687Methanothermococcus okinawensis IH1 chromosome, complete genomephosphoesterase PA-phosphatase-like protein7e-0650.8