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Query: NC_003997:467993:475807 Bacillus anthracis str. Ames, complete genome

Start: 475807, End: 476616, Length: 810

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This well studied laboratory strain (Porton isolate) is not virulent due to the loss of the two plasmids, pXO1 and pXO2. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_012659:467893:475707475707476516810Bacillus anthracis str. A0248, complete genomehypothetical protein4e-154543
NC_007530:467993:475807475807476616810Bacillus anthracis str. 'Ames Ancestor', complete genomehypothetical protein4e-154543
NC_005945:467427:475850475850476659810Bacillus anthracis str. Sterne, complete genomehypothetical protein4e-154543
NC_010337:2793667:282706228270622827835774Heliobacterium modesticaldum Ice1, complete genomephage tail component, n-terminal domain, putative3e-1168.9
NC_013921:1396500:140990214099021410696795Thermoanaerobacter italicus Ab9 chromosome, complete genomephage tail component4e-1168.9
NC_011898:3367457:338179533817953382568774Clostridium cellulolyticum H10, complete genomephage tail component8e-1167.8
NC_014393:4775452:479400947940094794785777Clostridium cellulovorans 743B chromosome, complete genomephage tail component9e-1167.8
NC_016627:4270949:430005943000594300832774Clostridium clariflavum DSM 19732 chromosome, complete genomephage putative tail component1e-1067.4
NC_014410:800500:825063825063825836774Thermoanaerobacterium thermosaccharolyticum DSM 571 chromosome,phage tail component3e-1065.9
NC_009012:1934107:194812619481261948899774Clostridium thermocellum ATCC 27405, complete genomephage putative tail component4e-1065.5
NC_016627:4323370:433899043389904339763774Clostridium clariflavum DSM 19732 chromosome, complete genomephage putative tail component9e-1064.3
NC_015520:2974048:297657529765752977348774Mahella australiensis 50-1 BON chromosome, complete genomephage tail component2e-0963.5
NC_010320:1268355:130148213014821302255774Thermoanaerobacter sp. X514 chromosome, complete genomephage putative tail component5e-0961.6
NC_014538:1598106:161212616121261612899774Thermoanaerobacter sp. X513 chromosome, complete genomephage tail component5e-0961.6
NC_009674:2678932:2685747268574726872401494Bacillus cytotoxicus NVH 391-98 chromosome, complete genomephage putative tail component2e-0860.1
NC_009253:2819000:282288728228872823615729Desulfotomaculum reducens MI-1 chromosome, complete genomephage putative tail component7e-0754.7
NC_014831:8965:4227042270437061437Thermaerobacter marianensis DSM 12885 chromosome, complete genomephage tail component2e-0652.8