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Query: NC_003997:467993:471271 Bacillus anthracis str. Ames, complete genome

Start: 471271, End: 471633, Length: 363

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This well studied laboratory strain (Porton isolate) is not virulent due to the loss of the two plasmids, pXO1 and pXO2. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_012659:467893:471171471171471533363Bacillus anthracis str. A0248, complete genomehypothetical protein2e-63240
NC_007530:467993:471271471271471633363Bacillus anthracis str. 'Ames Ancestor', complete genomehypothetical protein2e-63240
NC_005945:467427:471314471314471676363Bacillus anthracis str. Sterne, complete genomehypothetical protein2e-63240
NC_010184:3464707:348503534850353485397363Bacillus weihenstephanensis KBAB4, complete genomeputative prophage pi2 protein 404e-39159
NC_012659:3464500:347289434728943473265372Bacillus anthracis str. A0248, complete genomehypothetical protein1e-38157
NC_012581:755982:765324765324765695372Bacillus anthracis str. CDC 684 chromosome, complete genomehypothetical protein1e-38157
NC_007530:3462624:347299434729943473365372Bacillus anthracis str. 'Ames Ancestor', complete genomehypothetical protein1e-38157
NC_005945:3463199:347356934735693473940372Bacillus anthracis str. Sterne, complete genomehypothetical protein1e-38157
NC_003997:3462497:347286734728673473238372Bacillus anthracis str. Ames, complete genomehypothetical protein1e-38157
NC_014171:2519767:252472425247242525080357Bacillus thuringiensis BMB171 chromosome, complete genomeprophage protein 402e-35147
NC_011772:3749399:375934537593453759707363Bacillus cereus G9842, complete genomeputative prophage pi2 protein 404e-34143
NC_011772:2495972:250087625008762501238363Bacillus cereus G9842, complete genomeputative prophage pi2 protein 401e-30131
NC_010184:3631891:364646536464653646827363Bacillus weihenstephanensis KBAB4, complete genomeputative prophage pi2 protein 402e-29127
NC_003212:2592600:259896525989652599321357Listeria innocua Clip11262, complete genomehypothetical protein1e-26118
NC_008555:1204000:123279812327981233154357Listeria welshimeri serovar 6b str. SLCC5334, complete genomeconserved phage-related protein1e-22105
NC_002662:1042546:106050410605041060863360Lactococcus lactis subsp. lactis Il1403, complete genomeprophage pi2 protein 402e-21101
NC_018704:176088:212699212699213073375Amphibacillus xylanus NBRC 15112, complete genomehypothetical protein1e-0858.5
NC_014376:787460:825857825857826231375Clostridium saccharolyticum WM1 chromosome, complete genomehypothetical protein2e-0857.8
NC_007432:654904:687274687274687693420Streptococcus agalactiae A909, complete genomehypothetical protein1e-0755.1