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Query: NC_003997:467993:470014 Bacillus anthracis str. Ames, complete genome

Start: 470014, End: 470370, Length: 357

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This well studied laboratory strain (Porton isolate) is not virulent due to the loss of the two plasmids, pXO1 and pXO2. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_012659:467893:469914469914470270357Bacillus anthracis str. A0248, complete genomehypothetical protein4e-53206
NC_005945:467427:470057470057470413357Bacillus anthracis str. Sterne, complete genomehypothetical protein4e-53206
NC_007530:467993:470014470014470370357Bacillus anthracis str. 'Ames Ancestor', complete genomehypothetical protein4e-53206
NC_005945:3463199:347486534748653475221357Bacillus anthracis str. Sterne, complete genomehypothetical protein9e-41165
NC_003997:3462497:347416334741633474519357Bacillus anthracis str. Ames, complete genomehypothetical protein9e-41165
NC_007530:3462624:347429034742903474646357Bacillus anthracis str. 'Ames Ancestor', complete genomehypothetical protein9e-41165
NC_012581:755982:764043764043764399357Bacillus anthracis str. CDC 684 chromosome, complete genomehypothetical protein9e-41165
NC_012659:3464500:347419034741903474546357Bacillus anthracis str. A0248, complete genomehypothetical protein9e-41165
NC_010184:3464707:348632234863223486678357Bacillus weihenstephanensis KBAB4, complete genomeprophage pi2 protein 377e-41165
NC_014171:2519767:252345325234532523797345Bacillus thuringiensis BMB171 chromosome, complete genomeprophage protein 372e-27121
NC_011772:2495972:249961324996132499954342Bacillus cereus G9842, complete genomeprophage pi2 protein 375e-26116
NC_011772:3749399:376063237606323760976345Bacillus cereus G9842, complete genomeprophage pi2 protein 371e-24112
NC_010184:3631891:364776336477633648107345Bacillus weihenstephanensis KBAB4, complete genomeprophage pi2 protein 376e-24109
NC_002662:1042546:105918310591831059554372Lactococcus lactis subsp. lactis Il1403, complete genomeprophage pi2 protein 374e-1890.1
NC_008555:1204000:123149812314981231851354Listeria welshimeri serovar 6b str. SLCC5334, complete genomeconserved phage-related protein4e-1890.1
NC_018704:176088:211421211421211801381Amphibacillus xylanus NBRC 15112, complete genomehypothetical protein6e-1889.4
NC_003212:2592600:260026426002642600617354Listeria innocua Clip11262, complete genomehypothetical protein3e-1787
NC_007432:654904:685987685987686355369Streptococcus agalactiae A909, complete genomehypothetical protein9e-1579
NC_014376:787460:824588824588824965378Clostridium saccharolyticum WM1 chromosome, complete genomeprophage pi2 protein 378e-1579
NC_014393:2868846:288323428832342883614381Clostridium cellulovorans 743B chromosome, complete genomephage related protein6e-0856.2
NC_004116:1827351:184543918454391845783345Streptococcus agalactiae 2603V/R, complete genomehypothetical protein7e-0855.8
NC_010674:2328307:234180323418032342192390Clostridium botulinum B str. Eklund 17B, complete genomehypothetical protein9e-0648.9