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Query: NC_003997:4507939:4526490 Bacillus anthracis str. Ames, complete genome

Start: 4526490, End: 4526687, Length: 198

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This well studied laboratory strain (Porton isolate) is not virulent due to the loss of the two plasmids, pXO1 and pXO2. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_016771:4445815:446653744665374466734198Bacillus cereus NC7401, complete genomehypothetical protein1e-28124
NC_005945:4508304:452770145277014527898198Bacillus anthracis str. Sterne, complete genomehypothetical protein1e-28124
NC_017200:4520482:453870145387014538898198Bacillus thuringiensis serovar finitimus YBT-020 chromosome,hypothetical protein1e-27121
NC_011969:4432454:445329844532984453495198Bacillus cereus Q1 chromosome, complete genomehypothetical protein1e-27121
NC_005957:4502733:452348245234824523679198Bacillus thuringiensis serovar konkukian str. 97-27, completehypothetical protein1e-27121
NC_014171:4560061:458276245827624582959198Bacillus thuringiensis BMB171 chromosome, complete genomehypothetical protein5e-27119
NC_004722:4645678:466850046685004668697198Bacillus cereus ATCC 14579, complete genomehypothetical protein5e-27119
NC_006274:4563455:458304745830474583244198Bacillus cereus E33L, complete genomegroup-specific protein6e-27119
NC_011658:4492356:451276645127664512951186Bacillus cereus AH187 chromosome, complete genomehypothetical protein3e-26117
NC_012581:4509491:452885845288584529043186Bacillus anthracis str. CDC 684 chromosome, complete genomehypothetical protein3e-26117
NC_012659:4507966:452652945265294526714186Bacillus anthracis str. A0248, complete genomehypothetical protein3e-26117
NC_010184:4532262:455229445522944552479186Bacillus weihenstephanensis KBAB4, complete genomehypothetical protein6e-26115
NC_003909:4484278:450710045071004507285186Bacillus cereus ATCC 10987, complete genomehypothetical protein9e-26115
NC_011772:4638000:465753946575394657724186Bacillus cereus G9842, complete genomehypothetical protein2e-25114
NC_011725:4671432:469283146928314693016186Bacillus cereus B4264 chromosome, complete genomehypothetical protein2e-25114
NC_016779:4475425:449506044950604495245186Bacillus cereus F837/76 chromosome, complete genomehypothetical protein3e-25114
NC_011773:4569600:459214345921434592328186Bacillus cereus AH820 chromosome, complete genomehypothetical protein3e-25114
NC_012472:4515909:453566145356614535846186Bacillus cereus 03BB102, complete genomehypothetical protein3e-25114
NC_017208:4692478:471201247120124712197186Bacillus thuringiensis serovar chinensis CT-43 chromosome, completehypothetical protein9e-25112