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Query: NC_003997:4507939:4520492 Bacillus anthracis str. Ames, complete genome

Start: 4520492, End: 4520674, Length: 183

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This well studied laboratory strain (Porton isolate) is not virulent due to the loss of the two plasmids, pXO1 and pXO2. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_016779:4475425:448924644892464489428183Bacillus cereus F837/76 chromosome, complete genomehypothetical protein2e-1477.8
NC_012659:4507966:452051945205194520701183Bacillus anthracis str. A0248, complete genomehypothetical protein2e-1477.8
NC_012581:4509491:452292645229264523108183Bacillus anthracis str. CDC 684 chromosome, complete genomehypothetical protein2e-1477.8
NC_011773:4569600:458621145862114586393183Bacillus cereus AH820 chromosome, complete genomehypothetical protein2e-1477.8
NC_012472:4515909:452973045297304529912183Bacillus cereus 03BB102, complete genomehypothetical protein2e-1477.8
NC_005957:4502733:451740045174004517582183Bacillus thuringiensis serovar konkukian str. 97-27, completehypothetical protein2e-1477.8
NC_014335:4442500:445704744570474457229183Bacillus cereus biovar anthracis str. CI chromosome, completehypothetical protein2e-1477.8
NC_005945:4508304:452170345217034521885183Bacillus anthracis str. Sterne, complete genomehypothetical protein2e-1477.8
NC_007530:4507742:452061945206194520801183Bacillus anthracis str. 'Ames Ancestor', complete genomehypothetical protein2e-1477.8
NC_017208:4692478:470632347063234706505183Bacillus thuringiensis serovar chinensis CT-43 chromosome, completehypothetical protein9e-1475.5
NC_016771:4445815:446078244607824460964183Bacillus cereus NC7401, complete genomehypothetical protein2e-1374.7
NC_011969:4432454:444741144474114447593183Bacillus cereus Q1 chromosome, complete genomehypothetical protein2e-1374.7
NC_011658:4492356:450699945069994507181183Bacillus cereus AH187 chromosome, complete genomehypothetical protein2e-1374.7
NC_011772:4638000:465150746515074651689183Bacillus cereus G9842, complete genomehypothetical protein7e-1372.8
NC_010184:4532262:454656945465694546751183Bacillus weihenstephanensis KBAB4, complete genomehypothetical protein4e-1270.1
NC_011725:4671432:468680146868014686983183Bacillus cereus B4264 chromosome, complete genomehypothetical protein4e-1166.6
NC_017200:4520482:453295845329584533140183Bacillus thuringiensis serovar finitimus YBT-020 chromosome,hypothetical protein4e-0753.5
NC_003909:4484278:450112345011234501305183Bacillus cereus ATCC 10987, complete genomehypothetical protein4e-0753.5