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Query: NC_003997:4507939:4519684 Bacillus anthracis str. Ames, complete genome

Start: 4519684, End: 4519908, Length: 225

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This well studied laboratory strain (Porton isolate) is not virulent due to the loss of the two plasmids, pXO1 and pXO2. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017200:4520482:453215145321514532375225Bacillus thuringiensis serovar finitimus YBT-020 chromosome,hypothetical protein7e-36149
NC_005945:4508304:452089545208954521119225Bacillus anthracis str. Sterne, complete genomehypothetical protein7e-36149
NC_007530:4507742:451981145198114520035225Bacillus anthracis str. 'Ames Ancestor', complete genomehypothetical protein7e-36149
NC_014335:4442500:445623944562394456463225Bacillus cereus biovar anthracis str. CI chromosome, completehypothetical protein7e-36149
NC_005957:4502733:451659245165924516816225Bacillus thuringiensis serovar konkukian str. 97-27, completehypothetical protein7e-36149
NC_008600:4509793:452273345227334522957225Bacillus thuringiensis str. Al Hakam, complete genomehypothetical protein7e-36149
NC_012472:4515909:452892245289224529146225Bacillus cereus 03BB102, complete genomehypothetical protein7e-36149
NC_006274:4563455:457627145762714576495225Bacillus cereus E33L, complete genomegroup-specific protein7e-36149
NC_011658:4492356:450619145061914506415225Bacillus cereus AH187 chromosome, complete genomehypothetical protein7e-36149
NC_011725:4671432:468599546859954686219225Bacillus cereus B4264 chromosome, complete genomehypothetical protein7e-36149
NC_016779:4475425:448843844884384488662225Bacillus cereus F837/76 chromosome, complete genomehypothetical protein7e-36149
NC_016771:4445815:445997444599744460198225Bacillus cereus NC7401, complete genomehypothetical protein7e-36149
NC_012659:4507966:451971145197114519935225Bacillus anthracis str. A0248, complete genomehypothetical protein7e-36149
NC_012581:4509491:452211845221184522342225Bacillus anthracis str. CDC 684 chromosome, complete genomehypothetical protein7e-36149
NC_011969:4432454:444660344466034446827225Bacillus cereus Q1 chromosome, complete genomehypothetical protein7e-36149
NC_011773:4569600:458540345854034585627225Bacillus cereus AH820 chromosome, complete genomehypothetical protein7e-36149
NC_011772:4638000:465070146507014650925225Bacillus cereus G9842, complete genomehypothetical protein9e-36148
NC_014171:4560061:457612445761244576348225Bacillus thuringiensis BMB171 chromosome, complete genomehypothetical protein1e-35148
NC_004722:4645678:466174646617464661970225Bacillus cereus ATCC 14579, complete genomehypothetical protein5e-35146
NC_010184:4532262:454576345457634545987225Bacillus weihenstephanensis KBAB4, complete genomehypothetical protein5e-35145
NC_003909:4484278:450032045003204500541222Bacillus cereus ATCC 10987, complete genomehypothetical protein3e-31133
NC_017208:4692478:470557147055714705741171Bacillus thuringiensis serovar chinensis CT-43 chromosome, completehypothetical protein3e-1890.5