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Query: NC_003997:4507939:4519340 Bacillus anthracis str. Ames, complete genome

Start: 4519340, End: 4519663, Length: 324

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This well studied laboratory strain (Porton isolate) is not virulent due to the loss of the two plasmids, pXO1 and pXO2. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_012581:4509491:452177445217744522103330Bacillus anthracis str. CDC 684 chromosome, complete genomehypothetical protein3e-46183
NC_012472:4515909:452857845285784528907330Bacillus cereus 03BB102, complete genomehypothetical protein3e-46183
NC_008600:4509793:452238945223894522718330Bacillus thuringiensis str. Al Hakam, complete genomehypothetical protein3e-46183
NC_005945:4508304:452055145205514520874324Bacillus anthracis str. Sterne, complete genomehypothetical protein4e-46183
NC_014335:4442500:445589544558954456218324Bacillus cereus biovar anthracis str. CI chromosome, completehypothetical protein4e-46183
NC_007530:4507742:451946745194674519790324Bacillus anthracis str. 'Ames Ancestor', complete genomehypothetical protein4e-46183
NC_006274:4563455:457592745759274576250324Bacillus cereus E33L, complete genomegroup-specific protein1e-45181
NC_017208:4692478:470517247051724705495324Bacillus thuringiensis serovar chinensis CT-43 chromosome, completehypothetical protein3e-45179
NC_004722:4645678:466140246614024661725324Bacillus cereus ATCC 14579, complete genomehypothetical protein5e-45179
NC_005957:4502733:451624845162484516571324Bacillus thuringiensis serovar konkukian str. 97-27, completehypothetical protein1e-44178
NC_011969:4432454:444625944462594446582324Bacillus cereus Q1 chromosome, complete genomehypothetical protein1e-44178
NC_016771:4445815:445963044596304459953324Bacillus cereus NC7401, complete genomehypothetical protein1e-44178
NC_011725:4671432:468565146856514685974324Bacillus cereus B4264 chromosome, complete genomehypothetical protein9e-45178
NC_003909:4484278:449997344999734500296324Bacillus cereus ATCC 10987, complete genomehypothetical protein7e-45178
NC_017200:4520482:453180745318074532130324Bacillus thuringiensis serovar finitimus YBT-020 chromosome,hypothetical protein7e-45178
NC_010184:4532262:454541945454194545742324Bacillus weihenstephanensis KBAB4, complete genomehypothetical protein2e-43173
NC_011772:4638000:465035746503574650614258Bacillus cereus G9842, complete genomehypothetical protein9e-32135
NC_014171:4560061:457578045757804575992213Bacillus thuringiensis BMB171 chromosome, complete genomehypothetical protein3e-23107
NC_016779:4475425:448809444880944488231138Bacillus cereus F837/76 chromosome, complete genomehypothetical protein1e-0962
NC_012659:4507966:451936745193674519504138Bacillus anthracis str. A0248, complete genomehypothetical protein1e-0962
NC_011773:4569600:458505945850594585196138Bacillus cereus AH820 chromosome, complete genomehypothetical protein1e-0962
NC_011658:4492356:450584745058474505984138Bacillus cereus AH187 chromosome, complete genomehypothetical protein1e-0858.5