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Query: NC_003997:4507939:4511946 Bacillus anthracis str. Ames, complete genome

Start: 4511946, End: 4512365, Length: 420

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This well studied laboratory strain (Porton isolate) is not virulent due to the loss of the two plasmids, pXO1 and pXO2. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_012659:4507966:451197345119734512392420Bacillus anthracis str. A0248, complete genomehypothetical protein7e-67251
NC_014335:4442500:444586944458694446288420Bacillus cereus biovar anthracis str. CI chromosome, completehypothetical protein8e-67251
NC_005945:4508304:451263545126354513054420Bacillus anthracis str. Sterne, complete genomehypothetical protein7e-67251
NC_007530:4507742:451207345120734512492420Bacillus anthracis str. 'Ames Ancestor', complete genomehypothetical protein7e-67251
NC_006274:4563455:456750845675084567927420Bacillus cereus E33L, complete genomegroup-specific protein7e-67251
NC_012581:4509491:451349845134984513917420Bacillus anthracis str. CDC 684 chromosome, complete genomehypothetical protein7e-67251
NC_011773:4569600:457541745754174575836420Bacillus cereus AH820 chromosome, complete genomehypothetical protein2e-66250
NC_017200:4520482:452453145245314524953423Bacillus thuringiensis serovar finitimus YBT-020 chromosome,hypothetical protein6e-66248
NC_005957:4502733:450711045071104507529420Bacillus thuringiensis serovar konkukian str. 97-27, completehypothetical protein2e-65247
NC_003909:4484278:449013044901304490549420Bacillus cereus ATCC 10987, complete genomehypothetical protein2e-65247
NC_012472:4515909:451996345199634520382420Bacillus cereus 03BB102, complete genomehypothetical protein3e-65246
NC_008600:4509793:451384645138464514265420Bacillus thuringiensis str. Al Hakam, complete genomehypothetical protein3e-65246
NC_016779:4475425:447947944794794479898420Bacillus cereus F837/76 chromosome, complete genomehypothetical protein3e-65246
NC_011969:4432454:443471444347144435133420Bacillus cereus Q1 chromosome, complete genomehypothetical protein5e-59226
NC_016771:4445815:445019244501924450611420Bacillus cereus NC7401, complete genomehypothetical protein8e-59225
NC_011658:4492356:449640944964094496828420Bacillus cereus AH187 chromosome, complete genomehypothetical protein8e-59225
NC_010184:4532262:453664745366474537069423Bacillus weihenstephanensis KBAB4, complete genomehypothetical protein8e-56215
NC_011772:4638000:464155646415564641969414Bacillus cereus G9842, complete genomehypothetical protein4e-53206
NC_017208:4692478:469657046965704696983414Bacillus thuringiensis serovar chinensis CT-43 chromosome, completehypothetical protein4e-53206
NC_014171:4560061:456590045659004566319420Bacillus thuringiensis BMB171 chromosome, complete genomehypothetical protein4e-51199
NC_011725:4671432:467580746758074676226420Bacillus cereus B4264 chromosome, complete genomehypothetical protein4e-51199
NC_004722:4645678:465152346515234651942420Bacillus cereus ATCC 14579, complete genomehypothetical protein3e-50196