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Query: NC_003997:4507939:4508743 Bacillus anthracis str. Ames, complete genome

Start: 4508743, End: 4509021, Length: 279

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This well studied laboratory strain (Porton isolate) is not virulent due to the loss of the two plasmids, pXO1 and pXO2. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_012581:4509491:451029545102954510573279Bacillus anthracis str. CDC 684 chromosome, complete genomehypothetical protein2e-49194
NC_007530:4507742:450887045088704509148279Bacillus anthracis str. 'Ames Ancestor', complete genomehypothetical protein2e-49194
NC_005945:4508304:450943245094324509710279Bacillus anthracis str. Sterne, complete genomehypothetical protein2e-49194
NC_008600:4509793:451059845105984510876279Bacillus thuringiensis str. Al Hakam, complete genomehypothetical protein3e-49193
NC_012472:4515909:451671445167144516992279Bacillus cereus 03BB102, complete genomehypothetical protein3e-49193
NC_005957:4502733:450386145038614504139279Bacillus thuringiensis serovar konkukian str. 97-27, completehypothetical protein1e-48191
NC_006274:4563455:456426045642604564538279Bacillus cereus E33L, complete genomegroup-specific protein2e-48190
NC_004722:4645678:464827446482744648552279Bacillus cereus ATCC 14579, complete genomehypothetical protein4e-48189
NC_016771:4445815:444694444469444447222279Bacillus cereus NC7401, complete genomehypothetical protein1e-47188
NC_014335:4442500:444262044426204442898279Bacillus cereus biovar anthracis str. CI chromosome, completehypothetical protein5e-47186
NC_012659:4507966:450882145088214509048228Bacillus anthracis str. A0248, complete genomehypothetical protein1e-39161
NC_016779:4475425:447628144762814476508228Bacillus cereus F837/76 chromosome, complete genomehypothetical protein3e-39160
NC_011773:4569600:457221945722194572446228Bacillus cereus AH820 chromosome, complete genomehypothetical protein3e-39160
NC_011658:4492356:449321244932124493439228Bacillus cereus AH187 chromosome, complete genomehypothetical protein3e-39160
NC_014171:4560061:456270445627044562931228Bacillus thuringiensis BMB171 chromosome, complete genomehypothetical protein1e-38158
NC_011725:4671432:467261246726124672839228Bacillus cereus B4264 chromosome, complete genomehypothetical protein1e-38158
NC_003909:4484278:448693244869324487159228Bacillus cereus ATCC 10987, complete genomehypothetical protein5e-38156
NC_017200:4520482:452133845213384521565228Bacillus thuringiensis serovar finitimus YBT-020 chromosome,hypothetical protein5e-38156
NC_011772:4638000:463831846383184638545228Bacillus cereus G9842, complete genomehypothetical protein5e-38156
NC_017208:4692478:469333146933314693558228Bacillus thuringiensis serovar chinensis CT-43 chromosome, completehypothetical protein3e-37153
NC_010184:4532262:453344145334414533668228Bacillus weihenstephanensis KBAB4, complete genomehypothetical protein5e-37152