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Query: NC_003997:4507939:4507939 Bacillus anthracis str. Ames, complete genome

Start: 4507939, End: 4508370, Length: 432

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This well studied laboratory strain (Porton isolate) is not virulent due to the loss of the two plasmids, pXO1 and pXO2. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_012659:4507966:450796645079664508397432Bacillus anthracis str. A0248, complete genomehypothetical protein2e-79293
NC_012581:4509491:450949145094914509922432Bacillus anthracis str. CDC 684 chromosome, complete genomehypothetical protein2e-79293
NC_007530:4507742:450806645080664508497432Bacillus anthracis str. 'Ames Ancestor', complete genomehypothetical protein2e-79293
NC_005945:4508304:450862845086284509059432Bacillus anthracis str. Sterne, complete genomehypothetical protein2e-79293
NC_017200:4520482:452048245204824520913432Bacillus thuringiensis serovar finitimus YBT-020 chromosome,hypothetical protein3e-79292
NC_003909:4484278:448607144860714486508438Bacillus cereus ATCC 10987, complete genomehypothetical protein7e-79291
NC_011658:4492356:449235644923564492787432Bacillus cereus AH187 chromosome, complete genomehypothetical protein7e-79291
NC_016771:4445815:444613944461394446570432Bacillus cereus NC7401, complete genomehypothetical protein7e-79291
NC_011773:4569600:457136545713654571796432Bacillus cereus AH820 chromosome, complete genomehypothetical protein2e-78290
NC_008600:4509793:450979345097934510230438Bacillus thuringiensis str. Al Hakam, complete genomehypothetical protein2e-78290
NC_016779:4475425:447542544754254475856432Bacillus cereus F837/76 chromosome, complete genomehypothetical protein3e-78289
NC_012472:4515909:451590945159094516340432Bacillus cereus 03BB102, complete genomehypothetical protein3e-78289
NC_006274:4563455:456345545634554563886432Bacillus cereus E33L, complete genomehypothetical protein9e-78288
NC_005957:4502733:450305745030574503488432Bacillus thuringiensis serovar konkukian str. 97-27, completehypothetical protein7e-78288
NC_014171:4560061:456185145618514562282432Bacillus thuringiensis BMB171 chromosome, complete genomehypothetical protein8e-77285
NC_011725:4671432:467175646717564672187432Bacillus cereus B4264 chromosome, complete genomehypothetical protein8e-77285
NC_004722:4645678:464746946474694647900432Bacillus cereus ATCC 14579, complete genomehypothetical protein8e-77285
NC_017208:4692478:469247846924784692909432Bacillus thuringiensis serovar chinensis CT-43 chromosome, completehypothetical protein1e-76284
NC_010184:4532262:453258645325864533017432Bacillus weihenstephanensis KBAB4, complete genomeActivator of Hsp90 ATPase 1 family protein7e-75278
NC_014976:17909:323363233632770435Bacillus subtilis BSn5 chromosome, complete genomehypothetical protein6e-50195
NC_019896:2158223:216289821628982163332435Bacillus subtilis subsp. subtilis str. BSP1 chromosome, completehypothetical protein1e-49194
NC_020244:1875834:191197719119771912411435Bacillus subtilis XF-1, complete genomehypothetical protein1e-48191
NC_017195:1852935:188833818883381888697360Bacillus subtilis subsp. subtilis str. RO-NN-1 chromosome, completeYndB7e-34142
NC_014206:411143:425235425235425660426Geobacillus sp. C56-T3 chromosome, complete genomeactivator of Hsp90 ATPase 1 family protein2e-31134
NC_015703:5865921:587323558732355873651417Runella slithyformis DSM 19594 chromosome, complete genomeActivator of Hsp90 ATPase 1 family protein9e-1268.9
NC_002944:1781905:179401317940131794420408Mycobacterium avium subsp. paratuberculosis K-10, complete genomehypothetical protein9e-0855.5
NC_015391:448833:467915467915468364450Carnobacterium sp. 17-4 chromosome, complete genomehypothetical protein1e-0652