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Query: NC_003997:4473973:4495893 Bacillus anthracis str. Ames, complete genome

Start: 4495893, End: 4496684, Length: 792

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This well studied laboratory strain (Porton isolate) is not virulent due to the loss of the two plasmids, pXO1 and pXO2. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_012659:4474000:449592044959204496717798Bacillus anthracis str. A0248, complete genomeaminoglycoside phosphotransferase family protein4e-140497
NC_012581:4478036:449744444974444498241798Bacillus anthracis str. CDC 684 chromosome, complete genomeaminoglycoside phosphotransferase family protein4e-140497
NC_011773:4541306:455931945593194560116798Bacillus cereus AH820 chromosome, complete genomeaminoglycoside phosphotransferase family protein4e-140497
NC_007530:4474000:449602044960204496811792Bacillus anthracis str. 'Ames Ancestor', complete genomeaminoglycoside phosphotransferase family protein4e-140497
NC_014335:4414052:442982544298254430616792Bacillus cereus biovar anthracis str. CI chromosome, completeaminoglycoside phosphotransferase family protein3e-139494
NC_017208:4662500:468039346803934681190798Bacillus thuringiensis serovar chinensis CT-43 chromosome, completeputative choline kinase involved in lipopolysaccharide biosynthesis4e-138490
NC_011772:4606000:462536346253634626160798Bacillus cereus G9842, complete genomeaminoglycoside phosphotransferase family protein2e-137488
NC_017342:1462297:148200814820081482808801Staphylococcus aureus subsp. aureus TCH60 chromosome, completekanamycin kinase1e-66253
NC_017353:1235095:123771012377101238504795Staphylococcus lugdunensis N920143, complete genomehypothetical protein1e-65249
NC_007168:1167454:119503611950361195761726Staphylococcus haemolyticus JCSC1435, complete genomehypothetical protein5e-61234
NC_009004:1770497:179264717926471793420774Lactococcus lactis subsp. cremoris MG1363, complete genomeputative kinase9e-36150
NC_008023:1426687:144513614451361445927792Streptococcus pyogenes MGAS2096, complete genomePhosphotransferase enzyme family4e-33141
NC_007297:1406796:142679214267921427583792Streptococcus pyogenes MGAS5005, complete genomephosphotransferase enzyme family4e-33141
NC_008021:1401249:142124614212461422037792Streptococcus pyogenes MGAS9429, complete genomephosphotransferase enzyme family4e-33141