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Query: NC_003997:4473973:4495611 Bacillus anthracis str. Ames, complete genome

Start: 4495611, End: 4495889, Length: 279

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This well studied laboratory strain (Porton isolate) is not virulent due to the loss of the two plasmids, pXO1 and pXO2. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_012659:4474000:449563844956384495916279Bacillus anthracis str. A0248, complete genomehypothetical protein5e-40162
NC_012581:4478036:449716244971624497440279Bacillus anthracis str. CDC 684 chromosome, complete genomehypothetical protein5e-40162
NC_011969:4396000:441806844180684418346279Bacillus cereus Q1 chromosome, complete genomehypothetical protein5e-40162
NC_014335:4414052:442954344295434429821279Bacillus cereus biovar anthracis str. CI chromosome, completehypothetical protein5e-40162
NC_007530:4474000:449573844957384496016279Bacillus anthracis str. 'Ames Ancestor', complete genomehypothetical protein5e-40162
NC_011772:4606000:462508146250814625359279Bacillus cereus G9842, complete genomehypothetical protein2e-39160
NC_011773:4541306:455903745590374559315279Bacillus cereus AH820 chromosome, complete genomehypothetical protein2e-39160